Department of Immunology, Harvard Medical School, Boston, MA, USA.
Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Nat Rev Immunol. 2021 Sep;21(9):597-611. doi: 10.1038/s41577-021-00519-w. Epub 2021 Mar 26.
The FOXP3CD4 regulatory T (T) cells located in non-lymphoid tissues differ in phenotype and function from their lymphoid organ counterparts. Tissue T cells have distinct transcriptomes, T cell receptor repertoires and growth and survival factor dependencies that arm them to survive and operate in their home tissue. Their functions extend beyond immune surveillance to tissue homeostasis, including regulation of local and systemic metabolism, promotion of tissue repair and regeneration, and control of the proliferation, differentiation and fate of non-lymphoid cell progenitors. T cells in diverse tissues share a common FOXP3CD4 precursor located within lymphoid organs. This precursor undergoes definitive specialization once in the home tissue, following a multilayered array of common and tissue-distinct transcriptional programmes. Our deepening knowledge of tissue T cell biology will inform ongoing attempts to harness T cells for precision immunotherapeutics.
位于非淋巴器官中的 FOXP3CD4 调节性 T（T）细胞在表型和功能上与其淋巴器官对应物不同。组织 T 细胞具有独特的转录组、T 细胞受体库以及生长和存活因子依赖性，使它们能够在其原位组织中存活并发挥作用。它们的功能不仅限于免疫监视，还包括组织稳态的维持，包括局部和全身代谢的调节、组织修复和再生的促进，以及对非淋巴样细胞祖细胞的增殖、分化和命运的控制。不同组织中的 T 细胞共享位于淋巴器官内的共同 FOXP3CD4 前体。一旦进入原位组织，这个前体就会经历多层次的共同和组织特异性转录程序的明确特化。我们对组织 T 细胞生物学的深入了解将为正在进行的利用 T 细胞进行精确免疫治疗的尝试提供信息。
