IMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, (Barwon Health), PO Box 281, Geelong, VIC, 3220, Australia.
School of Health and Social Development, Deakin University, Geelong, Australia.
Eur Geriatr Med. 2021 Aug;12(4):887-892. doi: 10.1007/s41999-021-00490-8. Epub 2021 Mar 27.
To investigate the association between serum interleukin-6 (IL-6) and frailty.
Participants were 581 men aged 60-90 yr (median (IQR): 74 yr (67-83 yr)) from the Geelong Osteoporosis Study. Tallies of ≥ 3, 1-2 and 0 for weight loss/exhaustion/physical-inactivity/slowness/weakness indicated frailty, pre-frailty and robustness, respectively. Anthropometry, lower-limb muscle strength and physical performance were measured and health behaviours self-reported. Serum IL-6 was measured using an enzyme-linked immunosorbent assay and log-transformed (ln-IL-6). Total antioxidant capacity (TAC) was also measured using quantitative colorimetric determination. Multivariable ordinal logistic regression models tested associations between ln-IL-6 and frailty while considering age, anthropometry, comorbidities, TAC, medications that affect inflammatory processes, lifestyle and socioeconomic status.
There were 49(8.4%) frail and 315(54.2%) pre-fail men. A relationship was evident between ln-IL-6 and frailty before and after accounting for age (adjusted OR = 1.24, 95%CI 1.01-1.53). Adjusting for medications attenuated the association (OR = 1.20, 95%CI 0.98-1.48). No other confounders were identified.
These data suggest that IL-6 is positively associated with frailty in men, partly explained by advancing age and medications known to affect inflammation.
探讨血清白细胞介素-6（IL-6）与虚弱之间的关系。
参与者为来自 Geelong 骨质疏松研究的 581 名 60-90 岁男性（中位数（IQR）：74 岁（67-83 岁））。体重减轻/疲惫/体力活动减少/缓慢/虚弱的计分为≥3、1-2 和 0，分别表示虚弱、虚弱前期和稳健。测量人体测量学、下肢肌肉力量和身体表现，并自我报告健康行为。使用酶联免疫吸附测定法测量血清 IL-6，并进行对数转换（ln-IL-6）。使用定量比色法测定总抗氧化能力（TAC）。多变量有序逻辑回归模型在考虑年龄、人体测量学、合并症、TAC、影响炎症过程的药物、生活方式和社会经济地位的情况下，测试了 ln-IL-6 与虚弱之间的关联。
有 49 名（8.4%）虚弱男性和 315 名（54.2%）虚弱前期男性。在考虑年龄后，ln-IL-6 与虚弱之间存在明显关系（调整后的 OR=1.24，95%CI 1.01-1.53）。调整药物后，该关联减弱（OR=1.20，95%CI 0.98-1.48）。未发现其他混杂因素。
这些数据表明，IL-6 与男性的虚弱呈正相关，部分原因是年龄增长和已知影响炎症的药物。
