Liu Jiaxuan, Liu Zhenmin, Huang Jiaqi, Tao Renchuan
College of Stomatology, Guangxi Medical University, Guangxi, China.
Oral Dis. 2022 May;28(4):1058-1067. doi: 10.1111/odi.13861. Epub 2021 Apr 29.
To evaluate the effect of probiotics on gingival inflammation and oral microbiota in patients suffering from plaque-induced gingivitis. PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE were electronically searched until December 2020. The quality of included studies was assessed with the Cochrane Collaboration's Risk of Bias tool. The differences were expressed as weighted mean differences (WMD) and 95% of confidence interval (95% CI). I test was performed to evaluate the heterogeneity of the studies. All analyses were performed using Review Manager (version 5.3). Eleven randomized and controlled trials were included, enrolling 554 patients. All comparisons displayed that oral probiotics had no significant improvement in the Gingival Index (GI), Plaque Index (PI), and bleeding on probing (BOP) of patients with plaque-induced gingivitis. In terms of microecology, no significant difference in the volumes of gingival crevicular fluid (GCF), the concentration of IL-1β, and the counts of Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), and Fusobacterium nucleatum (Fn) were found between the probiotic group and the placebo group. There exists no clear evidence that oral probiotics have positive effect on gingival inflammation and oral microecological environment of patients with plaque-induced gingivitis.
评估益生菌对菌斑性牙龈炎患者牙龈炎症和口腔微生物群的影响。检索了PubMed、Cochrane对照试验中心注册库（CENTRAL）和EMBASE，检索截至2020年12月的文献。采用Cochrane协作网的偏倚风险工具评估纳入研究的质量。差异以加权平均差（WMD）和95%置信区间（95%CI）表示。进行I检验以评估研究的异质性。所有分析均使用Review Manager（版本5.3）进行。纳入了11项随机对照试验，共554例患者。所有比较均显示，口服益生菌对菌斑性牙龈炎患者的牙龈指数（GI）、菌斑指数（PI）和探诊出血（BOP）无显著改善。在微生态方面，益生菌组和安慰剂组在龈沟液（GCF）量、IL-1β浓度以及伴放线聚集杆菌（Aa）、牙龈卟啉单胞菌（Pg）、中间普氏菌（Pi）和具核梭杆菌（Fn）计数方面均未发现显著差异。没有明确证据表明口服益生菌对菌斑性牙龈炎患者的牙龈炎症和口腔微生态环境有积极作用。
