Cosmetics Safety and Efficacy Evaluation Centre, Sichuan University West China Hospital, 610041, China.
Sichuan Engineering Technology Research Centre of Cosmetic, 610041, China.
Oxid Med Cell Longev. 2022 Feb 9;2022:2422618. doi: 10.1155/2022/2422618. eCollection 2022.
The vermilion of the human lip, covered by a skinny epithelium with little melanin, is quite susceptible to damage from ultraviolet (UV) radiation exposure. However, commercial sunscreen filters and indelible dyes used in lipsticks can cause health hazards after percutaneous absorption or accidentally oral administration. Inspired by plant pigmentation as natural filters to protect themselves against overexposure to UV, safer bio-based sunscreens of cellulose enveloped with anthocyanin (AN) were developed using bionic design. Cellulose nanocrystals (CNC), derived from acid hydrolysis of cellulose, reinforced enhancement of UV absorption and shielding properties of AN. This innovation addresses the issue that naturally sourced UV filter application to sunscreen does not achieve a desired sun protection factor (SPF) value because of the low specific extinction value (E1,1). We also stated that the diverse formula of anthocyanin sunscreen lipsticks with CNC exhibited 10 times more SPF value than AN alone. Furthermore, they possess competitive benefits such as pleasing texture, superior adhesion, impermeable, nonphototoxicity, ease of application, and removal. This work provides a promising proof-of-concept for studying the features of natural sunscreens in the design of simple, safe, efficient, and green sunscreens.
人类嘴唇的红色部分由一层薄的上皮组织覆盖，含有少量黑色素，因此很容易受到紫外线（UV）辐射的伤害。然而，商业防晒霜中的过滤剂和口红中的永久性染料在经皮吸收或意外口服后可能会对健康造成危害。受植物色素作为天然过滤剂以防止过度暴露于 UV 的启发，我们采用仿生设计，开发了用花青素（AN）包裹纤维素的更安全的基于生物的防晒霜。纤维素纳米晶体（CNC）是通过酸水解纤维素得到的，增强了 AN 的紫外线吸收和屏蔽性能。这项创新解决了由于低比消光值（E1,1），天然来源的紫外线过滤剂在防晒霜中的应用无法达到理想的防晒因子（SPF）值的问题。我们还指出，含有 CNC 的花青素防晒霜口红的不同配方的 SPF 值比单独的 AN 高出 10 倍。此外，它们还具有令人愉悦的质地、卓越的附着力、不渗透、非光毒性、易于应用和去除等竞争优势。这项工作为研究天然防晒霜在设计简单、安全、高效和环保防晒霜方面的特性提供了有前途的概念验证。
