Dunn M M, Robinette D R, Peoples J B
Department of Surgery, Wright State University School of Medicine, Dayton, Ohio.
Am Surg. 1988 Jun;54(6):324-5.
It has been suggested that external stenting of synthetic vascular prosthetic material may improve patency rates in the low flow situation or across joints. This study compared externally stented polytetrafluoroethylene (PTFE) vascular grafts placed across the hip joint in dogs with nonstented PTFE grafts in regard to patency. Twenty animals underwent bilateral common iliac to common femoral artery bypass with proximal ligation of the femoral artery. In each animal one groin was randomly assigned to receive stented PTFE and the other nonstented PTFE. One animal was sacrificed at 2 weeks for graft infection. Nineteen animals received 38 grafts that remained in place 90-120 days. Patency was confirmed with angiography prior to sacrifice. Overall patency was 65 per cent with no significant difference between the two types of graft. Eighteen of 19 dogs (95%) had both the stented and nonstented PTFE grafts either open or closed. It is concluded that intrinsic factors, rather than external graft support, are a more important influence on graft patency in this model.
有人提出，对合成血管替代材料进行外部支撑，可能会提高低血流状态下或跨越关节处的血管通畅率。本研究比较了在犬类动物中，横跨髋关节放置的外部支撑聚四氟乙烯（PTFE）血管移植物与无支撑PTFE移植物的通畅情况。20只动物接受了双侧髂总动脉至股总动脉搭桥术，并对股动脉进行近端结扎。在每只动物中，随机选择一侧腹股沟接受支撑PTFE移植物，另一侧接受无支撑PTFE移植物。1只动物在2周时因移植物感染而处死。19只动物接受了38个移植物，这些移植物在体内留存90 - 120天。在处死前通过血管造影确认通畅情况。总体通畅率为65%，两种类型的移植物之间无显著差异。19只犬中有18只（95%）的支撑和无支撑PTFE移植物均通畅或堵塞。研究得出结论，在该模型中，内在因素而非移植物外部支撑，对移植物通畅情况的影响更为重要。
