Vento Torres M, Moya Benavent M, Doménech Martínez E
Departamento de Pediatría, Universidad de Alicante, Tenerife.
An Esp Pediatr. 1988 Mar;28(3):241-5.
Authors have studied: calcemia, bone ashes calcium content and bone turnover by histofluorescence in 44 Wistar female adult rats. Control group (A) received for 21 days (equivalent to pregnancy) a normocalcemic diet, and group B an hypocalcemic diet. Both received demethyl-chlortetracycline intra-peritoneally at the beginning and end of the experience. Fetuses were fully calcinated and ash weight and calcium content determined. Group B shows a significative decrease in calcemia (F = 284.66, p less than 0.01), bone ash calcium content (F = 47.2, p less than 0.01) and an increase in endosteal bone resorption (F = 32.89, p less than 0.01), while bone formation including synthesis of bone matrix and calcium deposition is diminished (total bone formation, F = 20.0, p less than 0.01). No significative differences have been found among rats of the same group for the fact of being pregnant. No differences have been detected among fetuses of both groups. Fetuses seem to act as parasites and authors support a possible explanation for neonatal hypocalcemia.
作者对44只成年雌性Wistar大鼠的血钙、骨灰钙含量和骨转换进行了组织荧光研究。对照组（A组）在21天（相当于孕期）内给予正常血钙饮食，B组给予低钙饮食。两组在实验开始和结束时均腹腔注射去甲基金霉素。将胎儿完全煅烧后测定骨灰重量和钙含量。B组血钙显著降低（F = 284.66，p < 0.01），骨灰钙含量降低（F = 47.2，p < 0.01），骨内膜骨吸收增加（F = 32.89，p < 0.01），而包括骨基质合成和钙沉积在内的骨形成减少（总骨形成，F = 20.0，p < 0.01）。同一组大鼠中，怀孕与否并无显著差异。两组胎儿之间未检测到差异。胎儿似乎起到了寄生虫的作用，作者为新生儿低钙血症提供了一种可能的解释。
