Departments of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Departments of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Asian Pac J Cancer Prev. 2021 Mar 1;22(3):705-709. doi: 10.31557/APJCP.2021.22.3.705.
Peripheral neurotoxicity is common in patients with digestive malignancies receiving chemotherapy containing oxaliplatin, and there is still no effective drug to prevent or treat this complication.
Seventy-nine patients receiving chemotherapy containing oxaliplatin were included, and the relationship between chemotherapy regimens, cycles, and cumulative dose of oxaliplatin and peripheral neurotoxicity was analyzed. Patients were divided into two groups of control or intervention. Twenty-eight patients in the control group received routine chemotherapy care, and 51 patients in the intervention group underwent two-week exercise rehabilitation program. Patients' Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - Neurotoxicity (FACT/GOG-Ntx), functional tests, and Brief Pain Inventory(BPI) scores as well as interference life scores were assessed before intervention and two weeks after the intervention.
In the intervention group, 52.9% patients previously exercised regularly. The FOLFOX regimen was more common in peripheral neurotoxicity (73.4%), and the median oxaliplatin cycles for neurotoxicity was 9 (ranging from 1 to 16). The mean cumulative dose of oxaliplatin was 1080.02 ± 185.22 mg, both the cycles and cumulative dose were positively correlated with the occurrence of peripheral neurotoxicity. Compared with control, the scores of FACT/GOG-Ntx, functional tests, and BPI were significantly decreased in the intervention group (p < 0.05).
Chemotherapy cycles and cumulative doses were in relation with OIN , and exercise rehabilitation program could effectively alleviate OIN.
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接受含奥沙利铂化疗的消化系统恶性肿瘤患者常发生周围神经毒性，目前尚无有效的药物预防或治疗这种并发症。
纳入 79 例接受含奥沙利铂化疗的患者，分析化疗方案、周期、奥沙利铂累积剂量与周围神经毒性的关系。将患者分为对照组和干预组。对照组 28 例患者接受常规化疗护理，干预组 51 例患者进行为期 2 周的运动康复方案。在干预前和干预后 2 周评估患者的癌症治疗功能评估/妇科肿瘤学组-神经毒性（FACT/GOG-Ntx）、功能测试、简明疼痛量表（BPI）评分和干扰生活评分。
干预组中 52.9%的患者之前有定期运动的习惯。奥沙利铂周围神经毒性更常见于 FOLFOX 方案（73.4%），神经毒性的奥沙利铂中位周期为 9 个（范围 1~16 个）。奥沙利铂的累积剂量平均为 1080.02±185.22mg，周期和累积剂量均与周围神经毒性的发生呈正相关。与对照组相比，干预组的 FACT/GOG-Ntx、功能测试和 BPI 评分均显著降低（p<0.05）。
化疗周期和累积剂量与 OIN 有关，运动康复方案可有效缓解 OIN。
