Department of Obstetrics, Gynecology and Women's Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN, USA; Program in Health Disparities Research, Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, MN, USA.
Department of Obstetrics, Gynecology and Women's Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN, USA.
Gynecol Oncol. 2022 Jul;166(1):85-89. doi: 10.1016/j.ygyno.2022.04.019. Epub 2022 May 5.
Physical activity is associated with improved cancer outcomes; however, it is unclear which patients may benefit most from increased physical activity. We evaluated whether associations between meeting the American Cancer Society (ACS) physical activity recommendations and psychosocial outcomes in gynecologic cancer survivors varied by type of treatments received.
We recruited English-speaking adult gynecologic cancer patients from an academic gynecologic oncology practice to participate in a prospective cohort study. Participants completed a survey at study entry regarding their psychosocial health-including distress, depression, anxiety, post-traumatic stress disorder, and quality of life (QoL)-and physical activity. Multivariate linear regression models for each psychosocial outcome tested for interactions between physical activity and each effect modifier (receipt of chemotherapy, radiation therapy, and/or minimally invasive surgery), adjusted for age, pain, body mass index, primary cancer diagnosis, cancer stage, time since diagnosis, and annual household income.
Among a total of 362 participants, 213 (59%) met ACS physical activity recommendations. We found evidence of interactions between physical activity and receipt of chemotherapy for depression, anxiety, and QoL scores; those who had received chemotherapy had a stronger association between physical activity and these psychosocial outcomes, compared to those who had not. We found no evidence of interactions between physical activity and receipt of radiation therapy or minimally invasive surgery for any of the outcomes.
Gynecologic cancer survivors who received chemotherapy had significant associations between psychosocial health and physical activity, suggesting they may derive greatest benefit from prescribed exercise.
身体活动与改善癌症预后相关；然而，尚不清楚哪些患者可能从增加身体活动中获益最大。我们评估了在妇科癌症幸存者中，符合美国癌症协会（ACS）身体活动建议与心理社会结局之间的关联是否因所接受的治疗类型而异。
我们从一家学术妇科肿瘤学诊所招募了讲英语的成年妇科癌症患者，以参与前瞻性队列研究。参与者在研究入组时完成了一项关于其心理社会健康的调查，包括困扰、抑郁、焦虑、创伤后应激障碍和生活质量（QoL）以及身体活动。对于每个心理社会结局，多变量线性回归模型测试了身体活动与每个修饰剂（接受化疗、放疗和/或微创手术）之间的交互作用，调整了年龄、疼痛、体重指数、原发癌症诊断、癌症分期、诊断后时间和家庭年收入。
在总共 362 名参与者中，有 213 名（59%）符合 ACS 身体活动建议。我们发现身体活动与化疗对抑郁、焦虑和 QoL 评分的相关性之间存在交互作用；与未接受化疗的患者相比，接受化疗的患者身体活动与这些心理社会结局之间的相关性更强。我们没有发现身体活动与接受放疗或微创手术之间对任何结局存在交互作用的证据。
接受化疗的妇科癌症幸存者的心理社会健康与身体活动之间存在显著关联，这表明他们可能从规定的运动中获益最大。
