Department of Medical Oncology 6, Vietnam National Cancer Hospital, Hanoi, Vietnam.
Department of Oncology, Vietnam University of Traditional Medicine, Hanoi, Vietnam.
Asian Pac J Cancer Prev. 2021 Mar 1;22(3):853-859. doi: 10.31557/APJCP.2021.22.3.853.
This study aimed to analyze the treatment outcome and toxicities, along with prognosis factors of patients with FIGO 2018 stage III cervical cancer treated with definitive concurrent chemoradiation.
A total of 83 stage III cervical cancer patients with good performance status (ECOG PS 0, 1) were treated with three-dimensional conformal radiation therapy (3D-CRT) combined with chemotherapy (weekly cisplatin), followed by high-dose-rate (HDR) brachytherapy between January 2017 and March 2019 at Vietnam National Cancer hospital. Treatment outcomes and prognosis factors were assessed along with acute and late toxicities.
The 3-year DFS was 67.8% and 3-year OS was 80.3%. On multivariate analyses, short axis of pelvic lymph node diameter of ≥ 15mm, invasion of the lower third of vagina and para-aortic lymph node metastasis were identified as adverse prognostic factors for DFS. The cumulative incidence rate of gastrointestinal and genitourinary toxicity (≥ grade 2) at the 3-year follow-up were 29.6% and 11.6%, respectively.
3D CRT and HDR brachytherapy with concurrent chemotherapy is an effective treatment, with acceptable toxicity for FIGO 2018 stage III cervical cancer in Vietnam.
.
本研究旨在分析采用根治性同期放化疗治疗国际妇产科联合会（FIGO）2018 分期 III 期宫颈癌患者的治疗结果和毒性反应，以及预后因素。
2017 年 1 月至 2019 年 3 月，越南国家癌症医院对 83 例一般状况良好（ECOG PS 0、1）的 III 期宫颈癌患者采用三维适形放疗（3D-CRT）联合化疗（每周顺铂）进行治疗，随后进行高剂量率（HDR）近距离放疗。评估治疗结果和预后因素以及急性和晚期毒性反应。
3 年无病生存率（DFS）为 67.8%，3 年总生存率（OS）为 80.3%。多因素分析显示，盆腔淋巴结短径≥15mm、阴道下段侵犯和腹主动脉旁淋巴结转移是 DFS 的不良预后因素。3 年随访时，胃肠道和泌尿生殖系统毒性（≥2 级）的累积发生率分别为 29.6%和 11.6%。
3D-CRT 和 HDR 近距离放疗联合化疗是一种有效的治疗方法，对越南FIGO 2018 分期 III 期宫颈癌具有可接受的毒性。
