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亚洲人群宫颈癌的预后因素:2013年至2023年研究的范围综述

Prognostic Factors for Cervical Cancer in Asian Populations: A Scoping Review of Research From 2013 to 2023.

作者信息

Abrar Syed S, Azmel Mohd Isa Seoparjoo, Mohd Hairon Suhaily, Yaacob Najib M, Ismail Mohd Pazudin

机构信息

Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MYS.

Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MYS.

出版信息

Cureus. 2024 Oct 13;16(10):e71359. doi: 10.7759/cureus.71359. eCollection 2024 Oct.

Abstract

Cervical cancer is the fourth most common cancer among women worldwide, with particularly high incidence and mortality rates in low- and middle-income countries, with Asia reporting the highest number of cases in 2022. Despite this significant burden, the prognostic factors specific to Asian populations remain underexplored. This scoping review aimed to identify and evaluate prognostic factors associated with cervical cancer outcomes in Asia, focusing on clinical, socio-demographic, and treatment-related variables. The review followed the Arksey and O'Malley framework and included 44 studies published between 2013 and 2023. The majority of research was concentrated in East Asia, particularly in China, Japan, and South Korea. Key prognostic factors affecting overall survival and disease-free survival included tumor size, histology, age, lymphovascular invasion, and lymph node metastasis. Non-squamous cell carcinoma histology, especially adenocarcinoma, was consistently linked to poorer outcomes. Older age and medical comorbidities, such as anemia and diabetes, also negatively impacted survival. Treatment-related factors, though less frequently reported, demonstrated the significance of adjuvant therapy, chemotherapy, and treatment intensity in improving outcomes. This review underscores the complexity of cervical cancer prognosis in Asian populations and highlights the need for targeted research and region-specific interventions to address the rising incidence of cervical cancer. It also highlights the scarcity of research on cervical cancer prognostic factors in West, Central, and South Asian countries. Future research should aim to address the gaps in understanding treatment-related factors and explore the potential for region-specific interventions to improve outcomes in cervical cancer across Asia.

摘要

宫颈癌是全球女性中第四大常见癌症,在低收入和中等收入国家的发病率和死亡率尤其高,亚洲在2022年报告的病例数最多。尽管负担如此沉重,但亚洲人群特有的预后因素仍未得到充分探索。本综述旨在识别和评估亚洲宫颈癌预后相关因素,重点关注临床、社会人口学和治疗相关变量。该综述遵循阿克西和奥马利框架,纳入了2013年至2023年发表的44项研究。大多数研究集中在东亚,尤其是中国、日本和韩国。影响总生存期和无病生存期的关键预后因素包括肿瘤大小、组织学类型、年龄、淋巴管浸润和淋巴结转移。非鳞状细胞癌组织学类型,尤其是腺癌,一直与较差的预后相关。高龄以及贫血和糖尿病等合并症也对生存期产生负面影响。治疗相关因素虽然报道较少,但显示出辅助治疗、化疗和治疗强度在改善预后方面的重要性。本综述强调了亚洲人群宫颈癌预后的复杂性,并强调需要开展针对性研究和针对特定区域的干预措施,以应对宫颈癌发病率不断上升的问题。它还凸显了西亚、中亚和南亚国家在宫颈癌预后因素研究方面的匮乏。未来的研究应致力于填补对治疗相关因素理解上的空白,并探索针对特定区域的干预措施改善亚洲各地宫颈癌预后的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de1/11556266/560ab94bb3a9/cureus-0016-00000071359-i01.jpg

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