Department of Pathology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, India.
Asian Pac J Cancer Prev. 2021 Mar 1;22(3):919-925. doi: 10.31557/APJCP.2021.22.3.919.
CD34 antigen is expressed by early hematopoietic progenitor cells and acute leukemia cells. Its expression is associated with good prognosis in acute myeloid leukemia. Literature is sparse on its prognostic significance in B- acute lymphoblastic leukemia (B-ALL) especially from India. Hence the present study was undertaken to analyse the frequency of CD34 expression in B-ALL in Indian patients and determine its prognostic significance by associating with other prognostic markers and aberrant antigen expression.
Seventy-five B-ALL patients diagnosed by flow cytometry over a period of 3½ year were studied. Correlation of CD34 expression was studied with gender, age, total leucocyte count (TLC), French-American-British (FAB) morphological type, immuno-phenotypic markers, cytogenetics and minimal residual disease. Differences between groups were evaluated using Student's T-test for quantitative data and Chi-square test/Fishers exact T-test for qualitative variables. P value.
CD34 抗原表达于早期造血祖细胞和急性白血病细胞。其表达与急性髓系白血病的良好预后相关。关于其在 B 急性淋巴细胞白血病（B-ALL）中的预后意义的文献较少，特别是来自印度的文献。因此，本研究旨在分析印度患者中 B-ALL 中 CD34 表达的频率，并通过与其他预后标志物和异常抗原表达相关联来确定其预后意义。
在 3 年半的时间内，通过流式细胞术诊断了 75 例 B-ALL 患者。研究了 CD34 表达与性别、年龄、总白细胞计数（TLC）、法国-美国-英国（FAB）形态学类型、免疫表型标志物、细胞遗传学和微小残留病之间的相关性。使用 Student's T 检验对定量数据和卡方检验/Fishers 确切 T 检验对定性变量进行组间差异评估。P 值。
