Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Bloco 13A, 05508-000 São Paulo, SP, Brazil.
Department of Food Science and Technology, Centro de Edafología y Biología Aplicada del Segura (CEBAS), Consejo Superior de Investigaciones Científicas (CSIC), Campus de Espinardo, Murcia 30100, Spain.
Food Res Int. 2021 Apr;142:110209. doi: 10.1016/j.foodres.2021.110209. Epub 2021 Feb 10.
Cagaita (Eugenia dysenterica DC) is an ellagitannin-containing Myrtaceae fruit from Cerrado biome. This fruit seems to be a promising candidate for an adjuvant in glucose regulation in healthy subjects. However, it is not known whether cagaita juice would have the same effect on dysglycemic subjects with metabolic syndrome (MetS). Therefore, the present work aimed to evaluate the effect of cagaita fruit juice on postprandial glycemia in dysglycemic subjects with MetS, and whether cagaita ellagitannins could be metabolized to urolithins. To evaluate glycemic effects, two different meals were consumed by volunteers (n = 12) with a 1-week interval among them. The first one consisted of white bread (50 g) plus water (300 mL) as a control; the second one, white bread (50 g) plus clarified cagaita juice (300 mL). Bioavailability was assessed in 24 h urine, after the consumption of a single amount of 300 mL of cagaita juice by healthy (n = 16) and MetS subjects (n = 7). The results showed that dysglycemic subjects with MetS presented a 53% reduction of incremental area under the curve (iAUC) of glucose, 38% reduction of insulin, 78% reduction of GIP (glucose-dependent insulinotropic polypeptide), and 58% reduction of C-peptide (p < 0.05), after the consumption of cagaita juice along with bread, in comparison to control water. However, both GLP-1 (glucagon-like peptide-1) and glucagon were not affected by cagaita juice ingestion. Concerning bioavailability, it was observed, for the first time, the metabolization of cagaita ellagitannins to urolithins by healthy and dysglycemic individuals with MetS, with a prevalence of metabotype B in both groups (44% and 42%, respectively), followed by metabotype A (37% and 29%, respectively), and metabotype 0 (19% and 29%, respectively).
卡加塔（Eugenia dysenterica DC）是桃金娘科含有鞣花单宁的果实，来自塞拉多生物群落。这种水果似乎是健康受试者葡萄糖调节的有前途的辅助剂候选物。然而，尚不清楚卡加塔果汁是否对患有代谢综合征（MetS）的糖调节受损者有相同的作用。因此，本工作旨在评估卡加塔果汁对糖调节受损伴有代谢综合征的受试者餐后血糖的影响，以及卡加塔鞣花单宁是否可代谢为尿石素。为了评估血糖效应，志愿者（n=12）在一周的间隔内食用两种不同的餐食。第一种餐食由白面包（50g）加 300mL 水组成，作为对照；第二种餐食由白面包（50g）加澄清卡加塔果汁（300mL）组成。在健康志愿者（n=16）和 MetS 受试者（n=7）单次饮用 300mL 卡加塔果汁后 24 小时的尿液中评估生物利用度。结果表明，糖调节受损伴有代谢综合征的受试者在食用卡加塔果汁加面包后，血糖增量曲线下面积（iAUC）降低 53%，胰岛素降低 38%，葡萄糖依赖性胰岛素释放肽（GIP）降低 78%，C 肽降低 58%（p<0.05），而胰高血糖素样肽-1（GLP-1）和胰高血糖素不受卡加塔果汁摄入的影响。关于生物利用度，首次观察到健康受试者和糖调节受损伴有代谢综合征的受试者可将卡加塔鞣花单宁代谢为尿石素，两组均以代谢型 B 为主（分别为 44%和 42%），其次是代谢型 A（分别为 37%和 29%），代谢型 0（分别为 19%和 29%）。
