Mandell A I, Bruce L A, Khalifa M A
Mid-South Glaucoma and Cataract Foundation, Memphis, Tennessee 38119.
Ann Ophthalmol. 1988 Apr;20(4):133-5.
Pilocarpine 4% gel and pilocarpine 4% solution were compared in young normal subjects for their effects on induced myopia. The pilocarpine 4% solution produced marked myopia lasting one to two hours which indicates that a qid therapeutic regimen produces about three to six hours of blurred vision during waking hours. The gel-induced myopic effects returned to normal in most subjects nine hours after a single instillation. Thus, pilocarpine-gel-induced myopic effects occur principally while asleep and are reduced substantially upon awakening. This allows patients to carry on normal activities throughout the day.
在年轻正常受试者中比较了4%毛果芸香碱凝胶和4%毛果芸香碱溶液对诱导性近视的影响。4%毛果芸香碱溶液可产生明显的近视，持续1至2小时，这表明每日四次的治疗方案在清醒时间会导致约3至6小时的视力模糊。在大多数受试者中，单次滴注凝胶后9小时，其引起的近视效应恢复正常。因此，毛果芸香碱凝胶引起的近视效应主要在睡眠时出现，醒来时会大幅减轻。这使得患者能够在一整天内进行正常活动。
