Place V A, Fisher M, Herbst S, Gordon L, Merrill R
Am J Ophthalmol. 1975 Oct;80(4):706-12. doi: 10.1016/0002-9394(75)90404-3.
Normal volunteers used 1, 2, and 4% pilocarpine eyedrops, three times daily, or ocular therapeutic systems placed in the conjunctival cul-de-sac to control intraocular pressure. The systems continuously release 20 and 40 mug/hour of pilocarpine for one week. Although the amount of drug delivered to the eye from the ocular therapeutic system was one fifth that obtained from the eyedrops, the decrease of intraocular pressure was comparable. The ocular therapeutic systems produced small, constant effects on visual acuity, refractive error, and miosis that did not cause visual handicaps or require correction. The effects of eyedrops on these visual factors were large and varied and produced marked visual handicaps that were not correctable with spectacles. Despite its comparable hypotensive effect in normal subjects, continuous delivery of pilocarpine by means of an ocular therapeutic system elicits less severe side effects than pilocarpine eyedrops.
正常志愿者使用1%、2%和4%的毛果芸香碱滴眼液，每日三次，或将眼用治疗系统置于结膜囊内以控制眼压。该系统持续一周以每小时20微克和40微克的速度释放毛果芸香碱。尽管从眼用治疗系统输送到眼部的药物量是滴眼液给药量的五分之一，但眼压降低程度相当。眼用治疗系统对视力、屈光不正和瞳孔缩小产生微小、持续的影响，不会导致视力障碍或需要矫正。滴眼液对这些视觉因素的影响大且多样，会产生明显的视力障碍，无法通过眼镜矫正。尽管在正常受试者中具有相当的降压效果，但通过眼用治疗系统持续输送毛果芸香碱引起的副作用比毛果芸香碱滴眼液轻。
