Brown H S, Meltzer G, Merrill R C, Fisher M, Ferré C, Place V A
Arch Ophthalmol. 1976 Oct;94(10):1716-9. doi: 10.1001/archopht.1976.03910040490004.
Eighteen glaucoma patients each received four pilocarpine regimens in random sequence: 1% and 4% eyedrops and 20mug/hr and 40mug/hr ocular therapeutic systems. Unimportant changes in refraction, near vision, and distance vision occurred during the use of either ocular therapeutic system. Miosis with ocular therapeutic systems was almost always less intense and variable than with eyedrops. Refractive changes occurred in 12 patients following 1% pilocarpine and in 16 patients following 4% pilocarpine drops; decreased distance vision occurred in nine patients after 1% drops and in 12 patients after 4% drops. Fewer patients showed decreases in near vision. In all cases, visual effects peaked one half hour after eyedrop instillations and returned gradually toward normal in the next two to three hours. Intraocular pressure levels were within comparable ranges during all four treatments, but the ocular therapeutic systems maintained pressure at a more constant level.
18名青光眼患者每人随机依次接受四种毛果芸香碱治疗方案：1%和4%眼药水以及20微克/小时和40微克/小时的眼部治疗系统。在使用任何一种眼部治疗系统期间，屈光、近视力和远视力均出现了无关紧要的变化。与眼药水相比，眼部治疗系统引起的瞳孔缩小几乎总是程度较轻且变化较小。1%毛果芸香碱治疗后有12名患者出现屈光变化，4%毛果芸香碱滴眼液治疗后有16名患者出现屈光变化；1%滴眼液治疗后有9名患者远视力下降，4%滴眼液治疗后有12名患者远视力下降。近视力下降的患者较少。在所有情况下，滴眼后半小时视觉效果达到峰值，并在接下来的两到三个小时内逐渐恢复正常。在所有四种治疗期间，眼压水平处于可比范围内，但眼部治疗系统使眼压维持在更稳定的水平。
