Graduate School, The Academic College at Wingate, The Wingate Institute, Netanya, Israel.
Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine and Sylvan Adams Sports Institute, Tel Aviv University, Tel Aviv, Israel.
Obes Res Clin Pract. 2021 May-Jun;15(3):221-226. doi: 10.1016/j.orcp.2021.03.001. Epub 2021 Mar 24.
Although over one hundred equations have been developed to predict the energy expenditure of individuals, none are sensitive to weight change in assessment of resting metabolic rate (RMR) before and after weight loss.
To formulate adjusted equations for overweight and obese individuals and to compare their accuracy with existing prediction RMR equations before and after weight loss.
SUBJECTS/MATERIALS: This is historical prospective study. Participants included 39 overweight and obese men and women before and after losing 10-20% from baseline weight on a diet and physical activity regimen for at least three months. Pre and post weight loss measured RMR results were compared to estimated RMR using several existing prediction equations: Harris and Benedict, Ravussin and Bogardus, and Mifflin et al. To improve the accuracy of these prediction equations, we suggest new equations adjusted for weight loss, based on measured RMR and evaluated their accuracy.
Pre and post weight loss data indicated: significant fat reduction in both genders; reduction in free-fat mass only in men, and a significant decrease in measured RMR only in women. Our suggested equations were the most accurate and closest to measured RMR in both genders, in comparison to the Harris and Benedict, Ravussin and Bogardus, and Mifflin et al equation results. Estimated RMR using the latter equations was significantly lower than measured RMR in both genders at pre and post weight loss (P < 0.01).
This study highlights the need for adjusting RMR equations before and after weight loss in overweight and obese individuals. Further research is needed to validate our suggested equations.
尽管已经开发出了超过一百个方程式来预测个体的能量消耗，但在评估减肥前后的静息代谢率（RMR）时，没有一个方程式对体重变化敏感。
为超重和肥胖个体制定调整后的方程式，并比较它们在减肥前后与现有预测 RMR 方程式的准确性。
受试者/材料：这是一项历史前瞻性研究。参与者包括 39 名超重和肥胖的男性和女性，他们在饮食和体育锻炼方案中至少减掉了基线体重的 10-20%，持续了至少三个月。将减肥前后测量的 RMR 结果与几种现有预测方程（Harris 和 Benedict、Ravussin 和 Bogardus 以及 Mifflin 等人）估计的 RMR 进行比较。为了提高这些预测方程的准确性，我们根据测量的 RMR 提出了新的调整后的方程，并评估了它们的准确性。
减肥前后的数据表明：两性的脂肪明显减少；只有男性的游离脂肪量减少，只有女性的测量 RMR 显著下降。与 Harris 和 Benedict、Ravussin 和 Bogardus 以及 Mifflin 等人的方程结果相比，我们提出的方程在两性中最准确，最接近测量的 RMR。使用后一组方程估计的 RMR 在减肥前后均明显低于测量的 RMR（P<0.01）。
本研究强调了在超重和肥胖个体中调整减肥前后 RMR 方程的必要性。需要进一步研究来验证我们提出的方程。
