Wei Cheong Tar, Al-Hassan Faisal Muti, Naim Norris, Knight Aishah, Joshi Sanmukh R
National Blood Transfusion Centre, Kuala Lumpur, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Malaysia.
Asian J Transfus Sci. 2013 Jan;7(1):26-8. doi: 10.4103/0973-6247.106725.
Diego blood group antigen, Di(a), is very rare among Caucasians and Blacks, but relatively common among the South American Indians and Asians of Mongolian origin. The antibody to Di(a) is clinically significant to cause hemolytic disease in a new-born or hemolytic transfusion reaction.
This study was designed to determine the prevalence of Di(a) antigen among the blood donors from the three major ethnic groups in Klang Valley of Malaysia as well as to find an incidence of an antibody of the Diego antigen, anti-Di(a), in a tertiary care hospital to ascertain the need to include Di(a+) red cells for an antibody screen cell panel.
Serological tests were performed by column agglutination technique using commercial reagents and following instruction as per kit insert.
Di(a) antigen was found with a frequency of 2.1% among the Malaysians donors in three ethnic groups viz, Malay, Chinese and Indian. It was present among 1.25% of 401 Malay, 4.01% of Chinese and 0.88% of 114 Indian origin donors. None of the 1442 patients, including 703 antenatal outpatients, had anti-Di(a) in serum.
The prevalence of Di(a) antigen was found among the donors of all the three ethnic background with varying frequency. Inclusion of Di(a+) red cells in routine antibody screening program would certainly help in detection of this clinically significant antibody and to provide safe blood transfusion in the Klang Valley, though the incidence of antibody appears to be very low in the region.
迭戈血型抗原Di(a)在高加索人和黑人中非常罕见，但在南美印第安人和蒙古人种起源的亚洲人中相对常见。抗Di(a)抗体在临床上可导致新生儿溶血病或溶血性输血反应。
本研究旨在确定马来西亚巴生谷三大主要族群献血者中Di(a)抗原的流行率，并在一家三级护理医院中寻找迭戈抗原抗体抗-Di(a)的发生率，以确定在抗体筛查细胞板中是否需要包含Di(a+)红细胞。
采用柱凝集技术，使用商业试剂并按照试剂盒说明书进行血清学检测。
在马来西亚的马来族、华族和印族三个族群的献血者中，Di(a)抗原的检出频率为2.1%。在401名马来族献血者中有1.25%、华族献血者中有4.01%以及114名印族献血者中有0.88%存在该抗原。在1442名患者中，包括703名产前门诊患者，血清中均未检测到抗-Di(a)。
在所有三个族群背景的献血者中均发现了不同频率的Di(a)抗原。在常规抗体筛查程序中纳入Di(a+)红细胞肯定有助于检测这种具有临床意义的抗体，并在巴生谷提供安全的输血，尽管该地区抗体的发生率似乎非常低。
