Farooqui A A, Liss L, Horrocks L A
Department of Physiological Chemistry, Ohio State University, Columbus 43210.
Ann Neurol. 1988 Mar;23(3):306-8. doi: 10.1002/ana.410230317.
The activities of monoacylglycerol and diacylglycerol lipases were 6 to 8 times higher in plasma membrane and synaptosomal plasma membrane fractions of nucleus basalis from patients with Alzheimer's disease than in those membranes from normal human brains. Membranes from the hippocampus region of Alzheimer-affected brains also showed consistently higher activities of monoacylglycerol and diacylglycerol lipases than those from control brains. These results indicate a stimulation of lipolytic enzymes in nucleus basalis and hippocampus regions in patients with Alzheimer's disease.
阿尔茨海默病患者基底核的质膜和突触体质膜部分中，单酰甘油脂肪酶和二酰甘油脂肪酶的活性比正常人脑的这些膜中的活性高6至8倍。受阿尔茨海默病影响的大脑海马区的膜中，单酰甘油脂肪酶和二酰甘油脂肪酶的活性也始终高于对照大脑的膜。这些结果表明，阿尔茨海默病患者基底核和海马区的脂解酶受到了刺激。
