Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin 300052, PR China.
Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin 300052, PR China.
Cell Immunol. 2021 Jun;364:104343. doi: 10.1016/j.cellimm.2021.104343. Epub 2021 Mar 15.
This study investigated the expression status of signaling lymphocytic activation molecule family 6 (SLAMF6) in CD8 T lymphocytes of patients with severe aplastic anemia (SAA) and its association with the clinical indicators and immune status of the disease. The effects of SLAMF6 on the function and apoptosis of CD8 T lymphocytes were also investigated. Levels of SLAMF6 and SLAM-associated protein in the CD8 T lymphocytes of SAA patients were significantly lower than the normal controls, and they were positively correlated with hematopoietic-related indicators but negatively correlated with the levels of functional molecules of CD8 T lymphocytes. After blocking SLAMF6, CD8 T lymphocyte functional molecule secretion was upregulated and RICD was downregulated in SAA patients, suggesting that SLAMF6, is involved in the pathogenetic mechanism of SAA by regulating CD8 T lymphocyte functional molecule secretion and RICD levels. SLAMF6 may be a novel target for the regulation of CD8 T lymphocyte homeostasis.
本研究探讨了信号淋巴细胞激活分子家族 6（SLAMF6）在重型再生障碍性贫血（SAA）患者 CD8 T 淋巴细胞中的表达状态及其与疾病临床指标和免疫状态的关系。还研究了 SLAMF6 对 CD8 T 淋巴细胞功能和凋亡的影响。SAA 患者 CD8 T 淋巴细胞中的 SLAMF6 和 SLAM 相关蛋白水平明显低于正常对照组，且与造血相关指标呈正相关，与 CD8 T 淋巴细胞功能分子水平呈负相关。阻断 SLAMF6 后，SAA 患者 CD8 T 淋巴细胞功能分子分泌上调，RICD 下调，提示 SLAMF6 通过调节 CD8 T 淋巴细胞功能分子分泌和 RICD 水平参与 SAA 的发病机制。SLAMF6 可能是调节 CD8 T 淋巴细胞稳态的新靶点。
