Neu H C, Novelli A, Saha G, Chin N X
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
Antimicrob Agents Chemother. 1988 Apr;32(4):580-3. doi: 10.1128/AAC.32.4.580.
The antibacterial activities of DuP 105 and DuP 721, new oxazolidinone antimicrobial agents, were compared with those of beta-lactams and glycopeptides. Ninety percent of Staphylococcus aureus and Staphylococcus epidermidis isolates, including methicillin-resistant isolates, were inhibited by 4 micrograms of DuP 105 and 1 microgram of DuP 721 per ml. DuP 721 inhibited hemolytic streptococcus groups A, B, C, F, and G at a concentration of less than or equal to 1 microgram/ml, and it inhibited viridans group streptococci at a concentration of 2 micrograms/ml. Both agents inhibited Listeria monocytogenes, Corynebacterium group JK species, anaerobic cocci, and Clostridium spp. including Clostridium difficile. They did not inhibit members of the family Enterobacteriaceae or Pseudomonas aeruginosa, but the MIC for 90% of Bacteroides fragilis isolates was 8 micrograms of DuP 721 per ml.
将新型恶唑烷酮类抗菌剂DuP 105和DuP 721的抗菌活性与β-内酰胺类和糖肽类抗菌剂进行了比较。每毫升含4微克DuP 105和1微克DuP 721可抑制90%的金黄色葡萄球菌和表皮葡萄球菌分离株，包括耐甲氧西林分离株。DuP 721在浓度小于或等于1微克/毫升时可抑制A、B、C、F和G组溶血性链球菌，在浓度为2微克/毫升时可抑制草绿色链球菌。这两种药物均可抑制单核细胞增生李斯特菌、JK组棒状杆菌属、厌氧球菌和梭菌属，包括艰难梭菌。它们不抑制肠杆菌科成员或铜绿假单胞菌，但90%脆弱拟杆菌分离株的最低抑菌浓度为每毫升8微克DuP 721。
