Department of Physiology, Necmettin Erbakan University Meram Medical School, Konya, Turkey.
Department of Biochemistry, Necmettin Erbakan Üniversity Meram Medical School, Konya, Turkey.
Biol Trace Elem Res. 2022 Feb;200(2):652-660. doi: 10.1007/s12011-021-02669-3. Epub 2021 Mar 28.
The objective of this study is to determine the synergistic effects of an antioxidant ion Mg, combined with selective serotonin reuptake inhibitor sertraline, in treatment or prevention of major depression and regulation of inotropic effect in the early postoperative period. Adult male 40 Wistar albino rats were randomly divided into 6 groups. Three to 4-mm long atrium strips were placed in organ bath, tension was adjusted to 2 g. Isometric contractions were induced with 10 M adrenaline. Group 1 was the control group, cumulative sertraline was given to group 2, cumulative MgSO to group 3, combined cumulative sertraline and MgSO to group 4, intraperitoneal sertraline injection for 29 days to group 5, and intraperitoneal MgSO injection for 14 days to group 6. Changes in weight, tensions, bleeding/clotting time, and biochemical findings were evaluated statistically. Isometric tension relationship between groups 1 and 3 was statistically significant after 4 mmol/L MgSO (p < 0.05). A rapid inhibition of contraction was observed in group 4. Inhibition of spontaneous contractions of groups 5 and 6 was found to be statistically significant at close values, p < 0.05. When blood clotting times were compared, a statistically marked decrease was found in group 6, p < 0.05. Compared to control group, there was a significant decrease in blood lipids in group 4. While LDH and CK-MB increased from plasma enzymes in groups 5 and 6, no significant change was observed in NT-proBNP. Combined treatment of high dose MgSO with antidepressants for pre or post-operative depression may cause fatal risks. Shortening clotting time may increase the risk of embolism and stroke. In order to reduce the risk of post-operative depression preoperatively, care should be taken when using magnesium combined with antidepressants and more studies are needed to be considered.
本研究旨在确定抗氧化剂离子 Mg 与选择性 5-羟色胺再摄取抑制剂舍曲林联合使用在治疗或预防重度抑郁症和调节术后早期变力效应方面的协同作用。将成年雄性 40 只 Wistar 白化大鼠随机分为 6 组。将 3 到 4mm 长的心房条放置在器官浴中，张力调整为 2g。用 10M 肾上腺素诱导等长收缩。第 1 组为对照组，第 2 组给予累积舍曲林，第 3 组给予累积 MgSO4，第 4 组给予累积舍曲林和 MgSO4，第 5 组给予腹腔内舍曲林注射 29 天，第 6 组给予腹腔内 MgSO4 注射 14 天。统计评估体重、张力、出血/凝血时间和生化发现的变化。第 1 组和第 3 组之间的等长张力关系在 4mmol/L MgSO4 后具有统计学意义（p<0.05）。第 4 组观察到收缩的快速抑制。第 5 组和第 6 组自发收缩的抑制被发现具有统计学意义，接近值 p<0.05。当比较凝血时间时，第 6 组有统计学显著降低，p<0.05。与对照组相比，第 4 组的血脂明显降低。虽然 LDH 和 CK-MB 从第 5 组和第 6 组的血浆酶中升高，但 NT-proBNP 没有观察到显著变化。在术前或术后使用抗抑郁药联合高剂量 MgSO4 治疗抑郁可能会导致致命风险。缩短凝血时间可能会增加栓塞和中风的风险。为了降低术前术后抑郁的风险，在使用镁联合抗抑郁药时应谨慎，并需要进行更多的研究。
