从 CAPNETZ 队列看十余年来社区获得性肺炎的细菌病因学变迁：数据资料
Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade.
机构信息
Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands.
Institute of Medical Microbiology and Hygiene, University Hospital of Ulm, Ulm, Germany.
出版信息
Infection. 2021 Jun;49(3):533-537. doi: 10.1007/s15010-021-01605-w. Epub 2021 Mar 27.
To determine the most relevant pathogens for CAP in Germany, patients with radiologically confirmed pulmonary infiltrates and at least one clinical sign of lung infection were prospectively recruited within the CAPNETZ cohort from 2004 until 2016. In 990 out of 4.672 patients (21%) receiving complete diagnostics the most prominent change of pathogens was a decrease of S. pneumoniae (58% in 2004 to 37.5% in 2016; p ≤ 0.001, ρ = - 0.148) and an increase of H. influenzae (12.2% to 20.8%; p = 0.001, ρ = 0.104).
为了确定德国 CAP 中最相关的病原体，自 2004 年至 2016 年，在 CAPNETZ 队列中前瞻性招募了经影像学证实肺部浸润且至少有一个肺部感染临床体征的患者。在接受完整诊断的 4672 名患者中的 990 名（21%）中，病原体最显著的变化是肺炎链球菌的减少（2004 年为 58%，2016 年为 37.5%；p≤0.001，ρ=−0.148）和流感嗜血杆菌的增加（12.2%至 20.8%；p=0.001，ρ=0.104）。
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