Department of Rheumatology and Connective Tissue Diseases, Medical University, Lublin, Poland.
Ann Agric Environ Med. 2021 Mar 18;28(1):189-192. doi: 10.26444/aaem/127801. Epub 2020 Sep 28.
Anti-PM/Scl (a-PM/Scl) antibodies are found in different systemic autoimmune diseases such as polymyositis, dermatomyositis, systemic sclerosis (SSc) and overlap syndromes. According to literature, they are detected in approx. 2% of SSc patients, but their presence is more common in SSc with myositis overlap.
The aim of the study was to assess the prevalence of a-PM/Scl in patients with SSc and to identify differences in the clinical profile of the disease in patients with the presence of a-PM/Scl.
The study was performed on 126 European Caucasian SSc patients (98 females and 28 males) hospitalized consecutively in the Department of Rheumatology and Connective Tissue Diseases. The study group was analyzed for the potential presence of a-PM/Scl using a commercial test - EUROLINE Systemic Sclerosis Profile. The detection and interpretation were carried out electronically using the specific Euroimmun - EUROLineScan programme. The subtype of SSc, incidence of internal organ involvement and serological profile were determined in the entire group. Due to the presence of a-PM/Scl, patients were divided into two groups: a-PM/Scl (+) SSc - 22 patients and a-PM/Scl (-) SSc - 104 patients.
A-PM/Scl was detected in 22/126 patients with SSc (17.5%). A strong correlation was found between a-PM/Scl and myalgia or myositis (p = 0.0379), hand joints contractures (p = 0.0002) and the prevalence of overlap syndrome (p = 0.0142). There were no relationships between the presence of a-PM/Scl and subtypes of SSc, other organ involvement, digital ulcers or calcinosis.
Anti-PM/Scl antibodies are fairly common in patients with systemic sclerosis. In SSc, anti-PM/Scl antibodies are frequently associated with myalgia or myositis, hand joint contractures and an overlap syndrome.
抗 PM/Scl（a-PM/Scl）抗体存在于多种自身免疫性疾病中，如多发性肌炎、皮肌炎、系统性硬皮病（SSc）和重叠综合征。根据文献报道，它们约存在于 2%的 SSc 患者中，但在伴有肌炎重叠的 SSc 患者中更为常见。
本研究旨在评估 SSc 患者中 a-PM/Scl 的患病率，并确定存在 a-PM/Scl 的患者疾病临床特征的差异。
本研究纳入了 126 名连续住院于风湿病和结缔组织疾病科的欧洲白种人 SSc 患者（98 名女性和 28 名男性）。使用商业试剂盒 EUROLINE 系统性硬皮病谱对研究组进行 a-PM/Scl 的潜在存在情况进行分析。使用特定的 Euroimmun-EUROLineScan 程序进行电子检测和解释。确定了整个组的 SSc 亚型、内脏器官受累发生率和血清学特征。由于存在 a-PM/Scl，患者被分为两组：a-PM/Scl（+）SSc-22 名患者和 a-PM/Scl（-）SSc-104 名患者。
在 126 名 SSc 患者中发现了 22 名（17.5%）存在 a-PM/Scl。a-PM/Scl 与肌痛或肌炎（p=0.0379）、手部关节挛缩（p=0.0002）和重叠综合征的患病率（p=0.0142）之间存在强烈相关性。a-PM/Scl 与 SSc 亚型、其他器官受累、手指溃疡或钙沉积之间没有关系。
抗 PM/Scl 抗体在系统性硬皮病患者中相当常见。在 SSc 中，抗 PM/Scl 抗体常与肌痛或肌炎、手部关节挛缩和重叠综合征相关。
