Greaves Breanna, Poindexter Lauren, Jensen Hanna
College of Medicine, University of Arkansas for Medical Sciences, Fayetteville, AR, USA.
Department of Physical Medicine and Rehabilitation, Division of Orthopedics and Sports Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Clin Med Insights Arthritis Musculoskelet Disord. 2025 Sep 2;18:11795441251370380. doi: 10.1177/11795441251370380. eCollection 2025.
Polymyositis with concomitant scleroderma is a rare, progressive condition with profound consequences if not addressed promptly. Severity and symptom presentation varies between patients, and much is unknown about how best to treat overlapping connective tissue diseases. This case discusses the rare presentation, medical evaluation, and successful treatment of a 46-year-old woman with excessive muscle atrophy, weakness, and tissue fibrosis, who was diagnosed with overlapping connective tissue disorder after extensive work up that included a muscle biopsy, skin punch biopsy, and autoantibody lab work. This patient recovered well with the use of mycophenolate mofetil demonstrating promising results for similar patients and offering insight into potential methods of evaluation and medical management. Studying cases like this one give providers more knowledge about overlapping connective tissue disease and how to best diagnose and manage them.
伴有硬皮病的多发性肌炎是一种罕见的进行性疾病，若不及时治疗会产生严重后果。患者之间的严重程度和症状表现各不相同，对于如何最佳治疗重叠性结缔组织病仍知之甚少。本病例讨论了一名46岁女性的罕见表现、医学评估及成功治疗过程，该患者存在肌肉过度萎缩、无力和组织纤维化，在经过包括肌肉活检、皮肤打孔活检和自身抗体实验室检查在内的全面检查后，被诊断为重叠性结缔组织病。该患者使用霉酚酸酯后恢复良好，这为类似患者带来了有希望的结果，并为潜在的评估方法和医疗管理提供了见解。研究此类病例能让医疗人员更多地了解重叠性结缔组织病以及如何最佳地诊断和管理它们。
