Dr. Du Rietz and Larsson are with Karolinska Institutet, Stockholm, Sweden. Dr. Larsson is also with the School of Medical Sciences, Örebro University, Örebro, Sweden.
Dr. Du Rietz and Larsson are with Karolinska Institutet, Stockholm, Sweden. Dr. Larsson is also with the School of Medical Sciences, Örebro University, Örebro, Sweden.
J Am Acad Child Adolesc Psychiatry. 2021 Oct;60(10):1178-1180. doi: 10.1016/j.jaac.2021.03.007. Epub 2021 Mar 25.
During the past 15 years, genome-wide association studies (GWASs) have been instrumental for identifying common genetic variants that influence complex traits. The latest attention-deficit/hyperactivity disorder (ADHD) GWAS, published in 2019, identified for the first time 12 loci significantly associated with ADHD. Since then a large number of studies have used the summary statistics of this GWAS to calculate individual polygenic scores (PGSs) in independent genotyped samples to explore how the ADHD PGS associates with relevant outcomes. The study by Ronald et al. synthesized the available literature on ADHD PGS and concluded that the ADHD PGS is robust and reliable, but not yet useful in clinical practice.
在过去的 15 年中，全基因组关联研究（GWAS）在确定影响复杂特征的常见遗传变异方面发挥了重要作用。2019 年发表的最新注意力缺陷多动障碍（ADHD）GWAS 首次确定了与 ADHD 显著相关的 12 个位点。此后，大量研究使用该 GWAS 的汇总统计数据在独立的基因分型样本中计算个体多基因评分（PGS），以探索 ADHD PGS 与相关结果的关联。Ronald 等人的研究综合了 ADHD PGS 的现有文献，得出结论认为 ADHD PGS 是可靠和稳定的，但尚未在临床实践中使用。
