来自垂序唐松草块根的 C-二萜生物碱。
C-diterpenoid alkaloids from the rhizomes of Aconitum pendulum.
机构信息
Key Laboratory of Medicinal Animal and Plant Resources of Qinghai-Tibetan Plateau in Qinghai Province, Qinghai Normal University, Xining 810008, China; Bijie Medical College, Bijie 551700, China.
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
出版信息
Fitoterapia. 2021 Jun;151:104887. doi: 10.1016/j.fitote.2021.104887. Epub 2021 Mar 26.
Six new C-aconitine-type diterpenoid alkaloids, pendulumines A-F (1-6), together with six known ones (7-12), were isolated from the rhizomes of Aconitum pendulum. Their structures were elucidated using extensive spectroscopic data analysis, including 1D and 2D NMR, MS, and single-crystal X-ray diffraction analysis. The isolates were also tested for their analgesic activity based on the thermal avoidance response of the roundworm Pirstionchus pacificus, and 9 showed significant biological activity with an EC value of 0.08 ± 0.02 mg.mL.
从铁棒锤的块根中分离得到了 6 个新的 C-乌头碱型二萜生物碱，pendulumines A-F（1-6），以及 6 个已知的生物碱（7-12）。通过包括 1D 和 2D NMR、MS 和单晶 X 射线衍射分析在内的广泛光谱数据分析，阐明了它们的结构。基于秀丽隐杆线虫的热回避反应，对分离得到的化合物进行了镇痛活性测试，其中 9 表现出显著的生物活性，EC 值为 0.08±0.02 mg.mL。
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