Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China; Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China.
Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China.
Fitoterapia. 2020 Jul;144:104609. doi: 10.1016/j.fitote.2020.104609. Epub 2020 May 7.
Kusnezosines A-C (1-3), three C-diterpenoid alkaloids with a new skeleton which featured an undescribed lactone type D-ring, were isolated from the roots of Aconitum kusnezoffii Reichb. var. gibbiferum. Kusnezosines A-C are the first naturally occurred C-diterpenoid alkaloids which possessing an unprecedented lactone D ring, this structure was formed by the cleavage of bond between C-15 and C-16 and a successive lactonization. Their structures were established on the basis of comprehensive spectroscopic data analysis. Besides, another 12 known ones were isolated from this plant, analgesic activity tests on the isolated alkaloids were also carried out.
库斯卡嗪 A-C（1-3），三种 C-二萜生物碱，具有一种新的骨架，其特征在于未描述的内酯型 D-环，从乌头属植物的根中分离得到。库斯卡嗪 A-C 是首次从天然来源中分离得到的具有前所未有的内酯 D 环的 C-二萜生物碱，该结构是通过 C-15 和 C-16 之间的键断裂和随后的内酯化形成的。它们的结构是基于综合光谱数据分析确定的。此外，还从该植物中分离出另外 12 种已知化合物，对分离出的生物碱进行了镇痛活性测试。
