因果关系？疾病中病原体与肠道微生物群的空间组织
Cause or effect? The spatial organization of pathogens and the gut microbiota in disease.
作者信息
Nguyen Jen, Pepin Deanna M, Tropini Carolina
机构信息
Department of Microbiology & Immunology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Department of Microbiology & Immunology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
出版信息
Microbes Infect. 2021 Jul-Aug;23(6-7):104815. doi: 10.1016/j.micinf.2021.104815. Epub 2021 Mar 26.
The human gut hosts a dense and diverse microbial community, spatially organized in multiple scales of structure. Here, we review how microbial organization differs between health and disease. We describe how changes in spatial organization may induce alterations in gut homeostasis, concluding with a future outlook to reveal causality.
人类肠道中存在着密集且多样的微生物群落，其在多个结构尺度上呈空间组织化分布。在此，我们综述了健康与疾病状态下微生物组织的差异。我们描述了空间组织的变化如何引发肠道稳态的改变，并对揭示因果关系的未来前景进行了展望。
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