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梓醇通过调节成骨细胞功能预防高糖诱导的骨质流失。

Catalpol Protects Against High Glucose-Induced Bone Loss by Regulating Osteoblast Function.

作者信息

Zhao Lu, Du Wei, Zhao Dandan, Ji Xueyan, Huang Yanfei, Pang Yong, Guo Kaijin, Yin Xiaoxing

机构信息

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China.

Department of Emergency Medicine Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

出版信息

Front Pharmacol. 2021 Mar 10;12:626621. doi: 10.3389/fphar.2021.626621. eCollection 2021.

DOI:10.3389/fphar.2021.626621
PMID:33776769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7987667/
Abstract

The overall objective of this study was to investigate the effects of catalpol on bone remodeling of diabetic osteoporosis by regulating osteoblast differentiation and migration. Using a murine model of diabetic osteoporosis, to detect the protective effects of catalpol on bone loss, architectural deterioration of trabecular bone and bone metabolism biomarkers were tested. A model of MC3T3-E1 cells was established by treatment with high glucose; the regulatory role of catalpol in the differentiation and migration was tested by Western blot, ALP staining, and Alizarin Red staining. Catalpol treatment markedly ameliorated trabecular bone deterioration by reducing degenerative changes of the trabecular structure by improving the bone formation marker levels of ALP, osteopontin, type I collagen, and osteocalcin, as well as the level of OPG/RANKL. Catalpol enhanced cell motility and scattering following gap formation of MC3T3-E1 cells. The results indicated that catalpol exhibits a protective effect against diabetic osteoporosis by regulating the differentiation and migration of osteoblast.

摘要

本研究的总体目标是通过调节成骨细胞分化和迁移来研究梓醇对糖尿病性骨质疏松症骨重塑的影响。使用糖尿病性骨质疏松症小鼠模型，检测梓醇对骨质流失的保护作用，测试小梁骨结构破坏情况和骨代谢生物标志物。通过高糖处理建立MC3T3-E1细胞模型；通过蛋白质免疫印迹法、碱性磷酸酶染色和茜素红染色测试梓醇在分化和迁移中的调节作用。梓醇治疗通过改善碱性磷酸酶、骨桥蛋白、I型胶原蛋白和骨钙素的骨形成标志物水平以及OPG/RANKL水平，减少小梁结构的退行性变化，显著改善小梁骨破坏。梓醇增强了MC3T3-E1细胞间隙形成后的细胞运动性和散射。结果表明，梓醇通过调节成骨细胞的分化和迁移对糖尿病性骨质疏松症具有保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/ed0ffdb1a8cc/fphar-12-626621-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/73ee45cbf09d/fphar-12-626621-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/c9ce64436595/fphar-12-626621-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/a685ea9201b1/fphar-12-626621-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/b4e1cc9f0e61/fphar-12-626621-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/3037bdd70d27/fphar-12-626621-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/71a1b405e0ed/fphar-12-626621-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/d25ac6d40688/fphar-12-626621-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/ed0ffdb1a8cc/fphar-12-626621-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/73ee45cbf09d/fphar-12-626621-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/c9ce64436595/fphar-12-626621-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/a685ea9201b1/fphar-12-626621-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/b4e1cc9f0e61/fphar-12-626621-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/3037bdd70d27/fphar-12-626621-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/71a1b405e0ed/fphar-12-626621-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/d25ac6d40688/fphar-12-626621-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/7987667/ed0ffdb1a8cc/fphar-12-626621-g008.jpg

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