Pantziarka Pan, Capistrano I Rica, De Potter Arno, Vandeborne Liese, Bouche Gauthier
The Anticancer Fund, Brussels, Belgium.
The George Pantziarka TP53 Trust, London, United Kingdom.
Front Pharmacol. 2021 Mar 11;12:627574. doi: 10.3389/fphar.2021.627574. eCollection 2021.
A global, comprehensive and open access listing of approved anticancer drugs does not currently exist. Partial information is available from multiple sources, including regulatory authorities, national formularies and scientific agencies. Many such data sources include drugs used in oncology for supportive care, diagnostic or other non-antineoplastic uses. We describe a methodology to combine and cleanse relevant data from multiple sources to produce an open access database of drugs licensed specifically for therapeutic antineoplastic purposes. The resulting list is provided as an open access database, (http://www.redo-project.org/cancer-drugs-db/), so that it may be used by researchers as input for further research projects, for example literature-based text mining for drug repurposing.
目前尚无全球范围内全面且开放获取的已批准抗癌药物清单。部分信息可从多个来源获取，包括监管机构、国家药品处方集和科研机构。许多此类数据源包含用于肿瘤学支持治疗、诊断或其他非抗肿瘤用途的药物。我们描述了一种方法，可对来自多个来源的相关数据进行整合与清理，以生成一个专门用于治疗性抗肿瘤目的的开放获取药物数据库。最终列表以开放获取数据库的形式提供（http://www.redo-project.org/cancer-drugs-db/），以便研究人员将其用作进一步研究项目的输入，例如用于药物重新利用的基于文献的文本挖掘。
