Llobet J M, Domingo J L, Corbella J
Laboratory of Toxicology and Biochemistry, Faculty of Medicine, University of Barcelona, Reus, Spain.
Arch Toxicol. 1988;61(4):321-3. doi: 10.1007/BF00364857.
Sixteen chelating agents were examined to determine their relative efficacy as antidotes in acute zinc acetate intoxication in mice after i.p. administration. For a i.p. dose of 0.49 mmol/kg (LD50) of zinc acetate, the i.p. administration of chelating agents at a 2:1 and 5:1 mole ratio resulted in a significant antidotal action for EDTA, DTPA, CDTA, D-penicillamine (D-PA), DMPS and DMSA. EGTA, L-cysteine, triethylentetraamine (TTHA), N-acetylcysteine (NAC), 4,5-dihydroxi-1,3-benzenedisulfonic acid (Tiron), sodium salicylate, glutathione, sodium diethyldithiocarbamate (DDC), 6-mercaptopurine and N-acetyl-D, L-penicillamine (NAPA) were not effective for acute zinc acetate poisoning. The therapeutic indices and therapeutic effectiveness of the most effective chelators were, respectively: EDTA (5.0, 7.0), DTPA (7.3, 13.7), CDTA (8.6, 6.3), D-PA (4.6, 1.9), DMPS (1.3, 1.0), DMSA (3.2, 5.4). DTPA, CDTA, and EDTA appear to be the most effective agents of those tested in offsetting acute zinc intoxication in mice.
研究了16种螯合剂，以确定它们腹腔注射给药后对小鼠急性醋酸锌中毒的相对解毒效果。对于腹腔注射0.49 mmol/kg（半数致死量）的醋酸锌，以2:1和5:1的摩尔比腹腔注射螯合剂时，乙二胺四乙酸（EDTA）、二乙烯三胺五乙酸（DTPA）、环己烷二胺四乙酸（CDTA）、D-青霉胺（D-PA）、二巯基丙磺酸钠（DMPS）和二巯基丁二酸（DMSA）产生了显著的解毒作用。乙二醇双乙醚二胺四乙酸（EGTA）、L-半胱氨酸、三亚乙基四胺（TTHA）、N-乙酰半胱氨酸（NAC）、4,5-二羟基-1,3-苯二磺酸（钛铁试剂）、水杨酸钠、谷胱甘肽、二乙基二硫代氨基甲酸钠（DDC）、6-巯基嘌呤和N-乙酰-D,L-青霉胺（NAPA）对急性醋酸锌中毒无效。最有效的螯合剂的治疗指数和治疗效果分别为：EDTA（5.0, 7.0）、DTPA（7.3, 13.7）、CDTA（8.6, 6.3）、D-PA（4.6, 1.9）、DMPS（1.3, 1.0）、DMSA（3.2, 5.4）。在抵消小鼠急性锌中毒方面，DTPA、CDTA和EDTA似乎是所测试的最有效药物。
