一种关于选择有毒金属螯合解毒剂的假说。

A hypothesis for the selection of chelate antidotes for toxic metals.

作者信息

Jones M M, Basinger M A

出版信息

Med Hypotheses. 1982 Nov;9(5):445-53. doi: 10.1016/0306-9877(82)90015-9.

Abstract

The problem of finding antidotes for toxic metal species for which antidotes have not been previously reported can be approached via a consideration of the metal-ion preferences of chelating agents already in clinical use. The metal ion preferences of six types of chelating agents together with information on antidotes used for other elements in the same family in the periodic table can be used to obtain a preliminary notion of which of these six structural types might furnish efficacious antidotes. The results of animal tests on a few of these chelate types can then serve as a guide in the selection of further compounds for testing. The data from the literature on antidotes for 20 toxic metal ions is summarized to assist the selection process.

摘要

对于此前未报道过解毒剂的有毒金属物种，寻找解毒剂的问题可以通过考虑临床中已使用的螯合剂对金属离子的偏好来解决。六种螯合剂的金属离子偏好以及元素周期表中同一族其他元素所使用解毒剂的信息，可用于初步了解这六种结构类型中的哪一种可能提供有效的解毒剂。然后，对其中几种螯合物类型进行动物试验的结果可作为选择进一步测试化合物的指导。总结了文献中关于20种有毒金属离子解毒剂的数据，以辅助选择过程。