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成功用芬戈莫德治疗中枢神经系统移植物抗宿主病。

Successful treatment with fingolimod of graft-versus-host disease of the central nervous system.

机构信息

Allogeneic Stem Cell Transplantation Unit, Department of Hematology.

Department of Neurology, Salengro Hospital.

出版信息

Blood Adv. 2018 Jan 2;2(1):10-13. doi: 10.1182/bloodadvances.2017011478. eCollection 2018 Jan 9.

DOI:10.1182/bloodadvances.2017011478
PMID:29344580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5761625/
Abstract

Fingolimod could be efficient to treat GVHD of the central nervous system.Further research should explore the use of fingolimod and other sphingosine-1-phosphate receptor agonists to prevent or treat GVHD.

摘要

芬戈莫德可能对治疗中枢神经系统移植物抗宿主病有效。应进一步研究芬戈莫德和其他鞘氨醇-1-磷酸受体激动剂在预防或治疗移植物抗宿主病中的作用。

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Successful treatment with fingolimod of graft-versus-host disease of the central nervous system.成功用芬戈莫德治疗中枢神经系统移植物抗宿主病。
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本文引用的文献

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Compositional changes of B and T cell subtypes during fingolimod treatment in multiple sclerosis patients: a 12-month follow-up study.多发性硬化症患者接受芬戈莫德治疗期间B细胞和T细胞亚群的组成变化：一项为期12个月的随访研究。
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The S1P1 receptor-selective agonist CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment.鞘氨醇-1-磷酸受体1（S1P1）选择性激动剂CYM-5442通过抑制巨噬细胞募集来减轻急性移植物抗宿主病（GVHD）的严重程度。
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FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway.FTY720 可独立于鞘氨醇-1-磷酸途径损害 CD8 T 细胞功能。
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FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin.FTY720通过促进脾脏调节性细胞的扩增并抑制免疫细胞浸润皮肤来改善小鼠硬皮病样慢性移植物抗宿主病。
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Central and peripheral nervous system immune mediated demyelinating disease after allogeneic hemopoietic stem cell transplantation for hematologic disease.血液病异基因造血干细胞移植后中枢及外周免疫介导的脱髓鞘疾病。
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Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis.多发性硬化症中鞘氨醇 1-磷酸受体调节剂 fingolimod（FTY720）的临床免疫学。
Neurology. 2011 Feb 22;76(8 Suppl 3):S20-7. doi: 10.1212/WNL.0b013e31820db341.
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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation.FTY720（芬戈莫德）在多发性硬化症动物模型中的疗效需要星形胶质细胞鞘氨醇 1-磷酸受体 1（S1P1）的调节。
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Graft-versus-host disease of the CNS after allogeneic bone marrow transplantation.异基因骨髓移植后中枢神经系统的移植物抗宿主病
J Clin Oncol. 2009 Oct 20;27(30):e147-9. doi: 10.1200/JCO.2009.21.7919. Epub 2009 Aug 10.
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Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).FTY720抑制移植物抗宿主病（GVHD）的机制及与调节性T细胞的兼容性研究
Blood. 2007 Nov 1;110(9):3480-8. doi: 10.1182/blood-2007-05-087940. Epub 2007 Jul 2.
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Regulation of donor T cells in the tolerant rats to graft-versus-host disease by FTY720 following small bowel transplantation.小肠移植后FTY720对耐受大鼠供体T细胞移植物抗宿主病的调控作用
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