Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, United States.
Unit of Endocrinology, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy.
Front Endocrinol (Lausanne). 2021 Mar 11;12:642568. doi: 10.3389/fendo.2021.642568. eCollection 2021.
Circulating albumin is negatively associated with adiposity but whether it is associated with increased energy intake, lower energy expenditure or weight gain has not been examined.
In (n=238; 146 men), we evaluated whether fasting albumin concentration was associated with 24-h energy expenditure and energy intake. In (n=325;167 men), we evaluated the association between plasma albumin and change in weight and body composition.
After adjustment for known determinants of energy intake lower plasma albumin concentration was associated with greater total daily energy intake (β= 89.8 kcal/day per 0.1 g/dl difference in plasma albumin, p=0.0047). No associations were observed between plasma albumin concentrations and 24-h energy expenditure or 24-h respiratory quotient (p>0.2). Over 6 years, volunteers gained on average 7.5 ± 11.7 kg (p<0.0001). Lower albumin concentrations were associated with greater weight [β=3.53 kg, p=0.039 (adjusted for age, sex, follow up time), CI 0.16 to 6.21 per 1 g/dl difference albumin concentration] and fat mass (β=2.3 kg, p=0.022), respectively, but not with changes in fat free mass (p=0.06).
Lower albumin concentrations were associated with increased food intake and weight gain, indicating albumin as a marker of energy intake regulation.
ClinicalTrials.gov, identifiers NCT00340132, NCT00342732.
循环白蛋白与肥胖呈负相关，但它是否与能量摄入增加、能量消耗降低或体重增加有关尚未得到检验。
在 （n=238；146 名男性）中，我们评估了空腹白蛋白浓度与 24 小时能量消耗和能量摄入的关系。在 （n=325；167 名男性）中，我们评估了血浆白蛋白与体重和身体成分变化之间的关系。
在校正了能量摄入的已知决定因素后，较低的血浆白蛋白浓度与更大的总日能量摄入相关（β=89.8 kcal/天，每 0.1 g/dl 血浆白蛋白差异，p=0.0047）。未观察到血浆白蛋白浓度与 24 小时能量消耗或 24 小时呼吸商之间存在相关性（p>0.2）。在 6 年期间，志愿者平均增重 7.5±11.7 kg（p<0.0001）。较低的白蛋白浓度与更大的体重[β=3.53 kg，p=0.039（调整年龄、性别、随访时间），CI 白蛋白浓度每 1 g/dl 差异 0.16 至 6.21 kg]和脂肪量（β=2.3 kg，p=0.022）相关，但与无脂肪量变化无关（p=0.06）。
较低的白蛋白浓度与增加的食物摄入和体重增加相关，表明白蛋白是能量摄入调节的标志物。
ClinicalTrials.gov，标识符 NCT00340132、NCT00342732。
