Li Yan, Zhang Jianqing
Department of Geosciences, Environment and Society, Université Libre De Bruxelles, 1050, Brussels, Belgium.
Sichuan University, Chengdu, 610065, China.
Toxicol Rep. 2021 Feb 23;8:548-556. doi: 10.1016/j.toxrep.2021.02.015. eCollection 2021.
This study was aimed at estimating the intake of lead and cadmium by the Belgian consumers due to the use of ceramic ware. We adopted refined exposure scenarios with respect to migrant concentration, ceramic ware usage, and metal release characteristics. A deterministic estimation was initially performed, followed by probabilistic estimation, if the deterministic estimate exceeds toxicological reference values. Based on the reference doses established by the European Food Safety Authority (EFSA), the risk of lead and cadmium exposure was characterized by the margin of exposure (MOE) and the tolerable weekly intake (TWI), respectively. The probabilistic median and 95th percentile intake of lead were 0.02 and 5.77 μg/kg b.w. per day for adults, and 0.07 and 17.3 μg/kg b.w. per day for children. The MOEs for neurotoxicity, nephrotoxicity and cardiovascular effects were 7.1, 27 and 64 for average consumers, and 0.02, 0.1 and 0.3 for high consumers. The deterministic mean and 95th percentile intake of cadmium were 0.026 (7% TWI) and 0.03 (8% TWI) μg/kg b.w. per day for adults, and 0.08 (22 % TWI) and 0.09 (25 % TWI) μg/kg b.w. per day for children. Considering the exposure of the Belgian population from foodstuffs resulted in the exceedance of the TWI by as much as 20-fold. The risk of exposure to lead and cadmium of the Belgian consumers suggests measures, such as lowering the migration limits for ceramic ware, should be taken to minimize the risk.
本研究旨在估算比利时消费者因使用陶瓷制品而摄入的铅和镉量。我们针对迁移浓度、陶瓷制品使用情况以及金属释放特性采用了精细的暴露情景。首先进行确定性估算,如果确定性估算超过毒理学参考值,则进行概率性估算。根据欧洲食品安全局(EFSA)确定的参考剂量,分别通过暴露边际(MOE)和可耐受每周摄入量(TWI)来表征铅和镉的暴露风险。成人铅的概率性中位数摄入量和第95百分位数摄入量分别为每天0.02和5.77μg/kg体重,儿童分别为每天0.07和17.3μg/kg体重。普通消费者神经毒性、肾毒性和心血管效应的MOE分别为7.1、27和64,高消费者分别为0.02、0.1和0.3。成人镉的确定性平均摄入量和第95百分位数摄入量分别为每天0.026(占TWI的7%)和0.03(占TWI的8%)μg/kg体重,儿童分别为每天0.08(占TWI的22%)和0.09(占TWI的25%)μg/kg体重。考虑到比利时人群从食品中的暴露导致TWI超标高达20倍。比利时消费者铅和镉的暴露风险表明应采取措施,如降低陶瓷制品的迁移限量,以将风险降至最低。