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铝从食品接触材料迁移至食品——对消费者的健康风险?三部分中的第一部分:铝的暴露、铝的释放、每周耐受摄入量(TWI)、铝的毒理学效应、研究设计及方法

Migration of aluminum from food contact materials to food-a health risk for consumers? Part I of III: exposure to aluminum, release of aluminum, tolerable weekly intake (TWI), toxicological effects of aluminum, study design, and methods.

作者信息

Stahl Thorsten, Falk Sandy, Rohrbeck Alice, Georgii Sebastian, Herzog Christin, Wiegand Alexander, Hotz Svenja, Boschek Bruce, Zorn Holger, Brunn Hubertus

机构信息

Hessian State Laboratory, Am Versuchsfeld 11, 34128 Kassel, Germany.

Hessian State Laboratory, Glarusstr. 6, 65203 Wiesbaden, Germany.

出版信息

Environ Sci Eur. 2017;29(1):19. doi: 10.1186/s12302-017-0116-y. Epub 2017 Apr 12.

DOI:10.1186/s12302-017-0116-y
PMID:28458989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5388732/
Abstract

BACKGROUND

In spite of the prevalence of aluminum in nature, no organism has been found to date which requires this element for its biological functions. The possible health risks to human beings resulting from uptake of aluminum include detrimental effects to the hemopoietic system, the nervous system and bones. Aluminum is used in many fields and occurs in numerous foodstuffs. Food contact materials containing aluminum represent an anthropogenic source of dietary aluminum.

RESULTS

As a result of their frequent use in private households a study was undertaken to detect migration of this metal to foodstuffs from drink containers, coffee pots, grill pans, and camping cookware made of aluminum.

CONCLUSIONS

An estimate of the health risk to consumers is calculated, based on the tolerable weekly intake (TWI) specified by the European Food Safety Authority of 1 mg/kg body weight for all groups of people. In some instances the TWI is significantly exceeded, dependent upon the food contact material and the food itself.

摘要

背景

尽管铝在自然界中普遍存在,但迄今为止尚未发现任何生物体需要这种元素来实现其生物学功能。人类摄入铝可能产生的健康风险包括对造血系统、神经系统和骨骼的有害影响。铝被广泛应用于许多领域,并且存在于众多食品中。含铝的食品接触材料是膳食铝的人为来源。

结果

鉴于这些材料在私人家庭中的频繁使用,开展了一项研究,以检测铝制饮料容器、咖啡壶、烤盘和野营炊具中这种金属向食品的迁移情况。

结论

根据欧洲食品安全局规定的所有人群每周可耐受摄入量(TWI)为每千克体重1毫克,计算了消费者面临的健康风险。在某些情况下,根据食品接触材料和食品本身的不同,TWI被大大超过。

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本文引用的文献

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Safety of aluminium from dietary intake - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC).膳食摄入铝的安全性——食品添加剂、香料、加工助剂及食品接触材料(AFC)小组的科学意见
EFSA J. 2008 Jul 15;6(7):754. doi: 10.2903/j.efsa.2008.754. eCollection 2008 Jul.
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Estimation of daily aluminum intake in Japan based on food consumption inspection results: impact of food additives.基于食品消费调查结果估算日本人的铝日摄入量:食品添加剂的影响。
Food Sci Nutr. 2014 Jul;2(4):389-97. doi: 10.1002/fsn3.114. Epub 2014 Apr 20.
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Aluminium in food and daily dietary intake estimate in Greece.希腊食物中的铝及日常膳食摄入量估算
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Elevated brain aluminium and early onset Alzheimer's disease in an individual occupationally exposed to aluminium: a case report.一例职业性接触铝的个体出现脑铝升高与早发型阿尔茨海默病:病例报告
J Med Case Rep. 2014 Feb 10;8:41. doi: 10.1186/1752-1947-8-41.
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Human exposure to aluminium.人体接触铝
Environ Sci Process Impacts. 2013 Oct;15(10):1807-1816. doi: 10.1039/c3em00374d.
6
Effect of aluminium on migratory and invasive properties of MCF-7 human breast cancer cells in culture.铝对 MCF-7 人乳腺癌细胞在培养中的迁移和侵袭特性的影响。
J Inorg Biochem. 2013 Nov;128:245-9. doi: 10.1016/j.jinorgbio.2013.07.004. Epub 2013 Jul 12.
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Aluminium neurotoxicity: neurobehavioural and oxidative aspects.铝神经毒性:神经行为及氧化方面
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Aluminosis--detection of an almost forgotten disease with HRCT.铝尘肺——利用高分辨率CT检测一种几乎被遗忘的疾病
J Occup Med Toxicol. 2006 Feb 17;1:4. doi: 10.1186/1745-6673-1-4.
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Aluminium, antiperspirants and breast cancer.铝、止汗剂与乳腺癌。
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Aluminum as a toxicant.铝作为一种有毒物质。
Toxicol Ind Health. 2002 Aug;18(7):309-20. doi: 10.1191/0748233702th157oa.