环状RNA介导的血管生成调控：癌症生物学的新篇章
CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology.
作者信息
Jiang Shaotao, Fu Rongdang, Shi Jiewei, Wu Huijie, Mai Jialuo, Hua Xuefeng, Chen Huan, Liu Jie, Lu Minqiang, Li Ning
机构信息
Department of HBP SURGERY II, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Department of Hepatic Surgery, The First People's Hospital of Foshan, Affiliated Foshan Hospital of Sun Yat-sen University, Foshan, China.
出版信息
Front Oncol. 2021 Mar 10;11:553706. doi: 10.3389/fonc.2021.553706. eCollection 2021.
Angiogenesis is necessary for carcinoma progression and is regulated by a variety of pro- and anti-angiogenesis factors. CircRNAs are RNA molecules that do not have a 5'-cap or a 3'-polyA tail and are involved in a variety of biological functions. While circRNA-mediated regulation of tumor angiogenesis has received much attention, the detailed biological regulatory mechanism remains unclear. In this review, we investigated circRNAs in tumor angiogenesis from multiple perspectives, including its upstream and downstream factors. We believe that circRNAs have natural advantages and great potential for the diagnosis and treatment of tumors, which deserves further exploration.
血管生成是癌进展所必需的，并受多种促血管生成和抗血管生成因子的调节。环状RNA（circRNAs）是一类没有5'帽或3'多聚腺苷酸尾的RNA分子，参与多种生物学功能。虽然circRNA介导的肿瘤血管生成调控已受到广泛关注，但其详细的生物学调控机制仍不清楚。在本综述中，我们从多个角度研究了circRNA在肿瘤血管生成中的作用，包括其上游和下游因子。我们认为，circRNA在肿瘤的诊断和治疗方面具有天然优势和巨大潜力，值得进一步探索。
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