Department of Pharmacognosy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144 411, Punjab, India.
Sharda School of Pharmacy, Gujarat Technical University, Gandhinagar 382 610, Gujarat, India.
Semin Cancer Biol. 2022 May;80:1-17. doi: 10.1016/j.semcancer.2019.12.008. Epub 2019 Dec 19.
The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of rapamycin (mTOR) represent two vital intracellular signaling pathways, which are associated with various aspects of cellular functions. These functions play vital roles in quiescence, survival, and growth in normal physiological circumstances as well as in various pathological disorders, including cancer. These two pathways are so intimately connected to each other that in some instances these are considered as one unique pathway crucial for cell cycle regulation. The purpose of this review is to emphasize the role of PI3K-Akt-mTOR signaling pathway in different cancer conditions and the importance of natural products targeting the PI3K-Akt-mTOR signaling pathway. This review also aims to draw the attention of scientists and researchers to the assorted beneficial effects of the numerous classes of natural products for the development of new and safe drugs for possible cancer therapy. We also summarize and critically analyze various preclinical and clinical studies on bioactive compounds and constituents, which are derived from natural products, to target the PI3K-Akt-mTOR signaling pathway for cancer prevention and intervention.
磷脂酰肌醇 3-激酶 (PI3K)-Akt 和雷帕霉素靶蛋白 (mTOR) 是两个重要的细胞内信号通路，与细胞功能的各个方面有关。这些功能在正常生理情况下的静止、存活和生长以及各种病理疾病中发挥着重要作用，包括癌症。这两个途径彼此之间密切相关，在某些情况下，它们被认为是一个独特的途径，对细胞周期调节至关重要。本文的目的是强调 PI3K-Akt-mTOR 信号通路在不同癌症情况下的作用，以及针对 PI3K-Akt-mTOR 信号通路的天然产物的重要性。本文还旨在引起科学家和研究人员的注意，注意到众多天然产物类别的各种有益作用，以便为可能的癌症治疗开发新的安全药物。我们还总结和批判性地分析了源自天然产物的生物活性化合物和成分针对 PI3K-Akt-mTOR 信号通路用于癌症预防和干预的各种临床前和临床研究。
