Abbasi Abdul Rahman, Liu Jinle, Wang Zhi, Zhao Anqi, Ying Hanjie, Qu Lingbo, Alam Md Asraful, Xiong Wenlong, Xu Jingliang, Lv Yongkun
School of Chemical Engineering, Zhengzhou University, Zhengzhou, China.
School of Agricultural Sciences, Zhengzhou University, Zhengzhou, China.
Front Bioeng Biotechnol. 2021 Mar 11;9:648382. doi: 10.3389/fbioe.2021.648382. eCollection 2021.
The sugar alcohols and functional sugars have wide applications in food, pharmaceutical, and chemical industries. However, the smaller quantities of natural occurring sugar alcohols and functional sugars restricted their applications. The enzymatic and whole-cell catalyst production is emerging as the predominant alternatives. The properties of make it a promising sugar alcohol and functional sugar producer. However, there are still some issues to be resolved. As there exist reviews about the chemical structures, physicochemical properties, biological functions, applications, and biosynthesis of sugar alcohols and/or functional sugars in , this mini review will not only update the recent advances in enzymatic and microbial production of sugar alcohols (erythritol, D-threitol, and xylitol) and functional sugars (isomaltulose, trehalose, fructo-oligosaccharides, and galacto-oligosaccharides) by using recombinant but also focus on the studies of gene discovery, pathway engineering, expanding substrate scope, bioprocess engineering, and novel breeding methods to resolve the aforementioned issues.
糖醇和功能性糖在食品、制药和化工行业有着广泛的应用。然而，天然存在的糖醇和功能性糖数量较少，限制了它们的应用。酶法和全细胞催化生产正成为主要的替代方法。其特性使其成为一种有前景的糖醇和功能性糖生产者。然而，仍有一些问题有待解决。由于已有关于糖醇和/或功能性糖的化学结构、物理化学性质、生物学功能、应用和生物合成的综述，本综述不仅将更新利用重组[具体内容缺失]进行糖醇（赤藓糖醇、D-苏糖醇和木糖醇）和功能性糖（异麦芽糖、海藻糖、低聚果糖和低聚半乳糖）酶法和微生物生产的最新进展，还将关注基因发现、途径工程、扩大底物范围、生物过程工程和新型育种方法等研究，以解决上述问题。
