Lopes Alessandra G D, Celestino Camila S H, Barros Tiago T A, Fevereiro Aline G, Gejer Debora H, Oliveira Fernando M F, Brasil Jamile M, Bossolan Rosely M, Pinto Gabriela C C, Santos Ana C E Z, Divan Luis A, Alves Ingrid A B, Oliveira Danielle B L, Machado Rafael R G, Thomazelli Luciano M, Hiyane Meire I, Brelaz-Abreu Leonília, Bragança-Jardim Elayne, Heinen Letícia B S, Barrientos Anna C M, Mau Luciana B, Camara Niels O S, Bueno Daniela F, Amano Mariane T
Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil.
Hospital Sírio-Libanês, São Paulo, Brazil.
Front Med (Lausanne). 2021 Mar 12;8:629112. doi: 10.3389/fmed.2021.629112. eCollection 2021.
Teenagers generally present mild to no symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the present report, we present the case of a 14-year-old boy with Angelman syndrome (AS) who presented with severe COVID-19 symptoms. He spent 20 days in the ICU with elevated inflammatory biomarkers (C-reactive protein and D-dimer) and increased peaks of neutrophil-to-lymphocyte ratio, which is uncommon for teenagers diagnosed with COVID-19. Although he showed physiological instability, he was able to produce neutralizing antibodies, suggesting a functional immune response. The literature concerning the immune response to infections in patients with AS is still poor, and to our knowledge, this was the first report of a patient with AS diagnosed with COVID-19. As such, the present study may alert other patients with AS or other rare diseases that they lack a competent immune response and could suffer severe consequences of SARS-CoV-2 infection.
青少年感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）通常表现为轻微症状或无症状。在本报告中，我们介绍了一名患有天使综合征（AS）的14岁男孩，他出现了严重的COVID-19症状。他在重症监护病房（ICU）待了20天，炎症生物标志物（C反应蛋白和D-二聚体）升高，中性粒细胞与淋巴细胞比值峰值增加，这在确诊COVID-19的青少年中并不常见。尽管他表现出生理不稳定，但他能够产生中和抗体，提示有功能性免疫反应。关于AS患者对感染的免疫反应的文献仍然很少，据我们所知，这是首例确诊COVID-19的AS患者报告。因此，本研究可能会提醒其他AS患者或其他罕见病患者，他们缺乏有效的免疫反应，可能会遭受SARS-CoV-2感染的严重后果。
