Stubbe Beate, Ittermann Till, Kaczmarek Sabine, Obst Anne, Bahls Martin, Bollmann Tom, Gläser Sven, Völzke Henry, Dörr Marcus, Ewert Ralf
Cardiology, Pneumology, Infectious Diseases and Intensive Care Medicine, Dept of Internal Medicine B, University Hospital Greifswald, Greifswald, Germany.
These authors contributed equally.
ERJ Open Res. 2021 Mar 22;7(1). doi: 10.1183/23120541.00350-2020. eCollection 2021 Jan.
Cardiopulmonary exercise testing (CPET) is a frequently used method for the evaluation of the cardiorespiratory system. The prognostic relevance of the measured parameters is commonly known. Longitudinal data on cardiorespiratory fitness in a large sample of well-characterised healthy volunteers are rare in the literature.
CPET data of 615 healthy individuals who voluntarily took part in the Study of Health in Pomerania (SHIP) at three different measurement times were analysed. The median observation time was 10.5 years. The age range was 25-85 years.
Over the observed timeframe and with increasing age, a decline in maximum power, peak oxygen uptake (') and oxygen uptake at anaerobic threshold (' @AT) was detectable. This decline was aggravated with increasing age. For the minute ventilation (')/carbon dioxide production (' ) slope, an increase was measured in individuals aged ≥50 years only.
The present study affirms the decrease in aerobic capacity with increasing age in a selected, well-characterised, healthy study sample, which seems to be less pronounced in females.
心肺运动试验（CPET）是评估心肺系统常用的方法。所测参数的预后相关性是众所周知的。文献中关于大量特征明确的健康志愿者心肺适能的纵向数据很少。
分析了615名自愿参加波美拉尼亚健康研究（SHIP）的健康个体在三个不同测量时间的CPET数据。中位观察时间为10.5年。年龄范围为25 - 85岁。
在观察期内，随着年龄增长，最大运动功率、峰值摄氧量（ ）和无氧阈摄氧量（ @AT）均有下降。且这种下降随着年龄增长而加剧。仅在年龄≥50岁的个体中，测得分钟通气量（ ）/二氧化碳排出量（ ）斜率增加。
本研究证实，在一个经过挑选、特征明确的健康研究样本中，有氧能力随年龄增长而下降，这在女性中似乎不太明显。
