Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
Sci Rep. 2018 Oct 30;8(1):16066. doi: 10.1038/s41598-018-34468-7.
Physical activity (PA) reduces the risk for mortality. Whether the beneficial effects of PA are domain specific is unclear. We associated leisure time (LTPA), sports (SPA) and work (WPA) related PA and cardiorespiratory fitness (CRF) with all-cause mortality in two German population-based cohorts. We used data of the Study of Health in Pomerania (SHIP, n = 2,935, median age 53; 48% male) and the Cardiovascular Disease, Living and Ageing in Halle study (CARLA, n = 1,776, median age 64 and 54% male). Mortality was determined after a median follow-up of 8.2 years in SHIP (n = 332) and 11.5 years in CARLA (n = 409). LTPA (SHIP: hazard ratio [HR] per standard deviation [SD] 0.82 95%-CI 0.73 to 0.91 and CARLA: HR per SD 0.70: 95%-CI 0.59 to 0.82) and SPA (SHIP: HR per SD 0.80 95%-CI 0.71 to 0.91 and CARLA: HR per SD 0.70 95%-CI 0.60 to 0.82) but not WPA were inversely associated with all-cause mortality. In a subsample CRF was inversely related to mortality and positively to LTPA and sports SPA. No association was found for WPA. Our results may suggest that the inverse association between PA and mortality are partly influenced by higher CRF.
体力活动（PA）可降低死亡率。PA 的有益影响是否具有特定领域尚不清楚。我们将休闲时间（LTPA）、运动（SPA）和工作（WPA）相关的 PA 以及心肺适能（CRF）与两个德国基于人群的队列的全因死亡率相关联。我们使用了来自波美拉尼亚健康研究（SHIP，n=2935，中位年龄 53 岁；48%为男性）和哈雷心血管疾病、生活和老龄化研究（CARLA，n=1776，中位年龄 64 岁，54%为男性）的数据。在 SHIP（n=332）和 CARLA（n=409）中，中位随访时间分别为 8.2 年和 11.5 年后，确定了死亡率。LTPA（SHIP：每标准偏差的危险比[HR]为 0.82 95%-CI 为 0.73 至 0.91，CARLA：每 SD 的 HR 为 0.70：95%-CI 为 0.59 至 0.82）和 SPA（SHIP：每 SD 的 HR 为 0.80 95%-CI 为 0.71 至 0.91，CARLA：每 SD 的 HR 为 0.70：95%-CI 为 0.60 至 0.82），但不是 WPA，与全因死亡率呈负相关。在一个亚样本中，CRF 与死亡率呈负相关，与 LTPA 和运动 SPA 呈正相关。未发现 WPA 与死亡率之间存在关联。我们的结果可能表明，PA 与死亡率之间的反比关系部分受到更高的 CRF 的影响。
