生物标志物在全关节置换术感染诊断中的作用不断扩大：当前文献综述
The Expanding Role of Biomarkers in Diagnosing Infection in Total Joint Arthroplasty: A Review of Current Literature.
作者信息
Sayan Ardalan, Kopiec Adam, Shahi Alisina, Chowdhry Madhav, Bullock Matthew, Oliashirazi Ali
机构信息
Department of Orthopaedics, Marshall University - Joan C. Edwards School of Medicine, Huntington, WV, USA.
出版信息
Arch Bone Jt Surg. 2021 Jan;9(1):33-43. doi: 10.22038/abjs.2020.42989.2169.
Abstract
Consistent diagnosis of periprosthetic infection in total joint arthroplasty continues to elude the orthopedic surgeon because no gold standard test exists. Therefore clinicians must rely on a combination of tests to help aid the diagnosis. The expanding role of biomarkers has shown promising results to more accurately diagnose an infection when combined with clinical suspicion and bacterial culture testing. This paper reviews the diagnostic capabilities of the most current serum and synovial biomarkers as well as next generation sequencing in the setting of periprosthetic joint infection. Future research and high-powered studies will be necessary to determine sensitivity and specificity of each biomarker.
摘要
由于不存在金标准检测方法，全关节置换术中假体周围感染的一致性诊断仍然困扰着骨科医生。因此，临床医生必须依靠多种检测方法的组合来辅助诊断。生物标志物作用的不断扩大已显示出有前景的结果，当与临床怀疑和细菌培养检测相结合时，能更准确地诊断感染。本文综述了当前血清和滑膜生物标志物以及假体周围关节感染情况下的下一代测序的诊断能力。未来的研究和大规模研究对于确定每种生物标志物的敏感性和特异性将是必要的。
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