Gold Deborah T, Weiss Richard, Beckett Tammy, Deal Chad, Epstein Robert S, James Andrew L, Kernaghan Jacqueline M, Mohseni Mahshid, Spiegel Michael, Vokes Tamara, Roberts Jenna, Bailey Tom, Wang Yamei, Williams Setareh A
Departments of Psychiatry & Behavioral Sciences and Sociology Duke University Medical Center Durham NC USA.
Global Medical Affairs Radius Health, Inc. Waltham MA USA.
JBMR Plus. 2021 Feb 4;5(3):e10457. doi: 10.1002/jbm4.10457. eCollection 2021 Mar.
Despite the availability of various osteoporosis treatments, adherence remains suboptimal. One contributing factor may be patient experience with therapy. This US, multicenter, combined retrospective chart review and patient questionnaire study included postmenopausal women at high risk for fracture and is the first study to describe real-world patient experience with abaloparatide (ABL) injection. Eight geographically diverse secondary care sites in the United States participated ( = 193). Mean ± SD age was 67.4 ±8.62 years. Most patients (86%) were satisfied with the ABL regimen, especially with ease of preparation (82%), ease of storage (87%), and storage convenience (89%), an attribute 83% of the patients thought was important. The majority of patients reported complete satisfaction with the ABL regimen allowing for their ability to conduct daily activities (85%) and convenience to fit into their daily schedule (84%). All reported taking ABL as directed, by injection in the lower abdomen, and 83% of patients reported medium or high adherence. Patients were satisfied with the needle size (76% completely satisfied), and 93% reported never deliberately missing a dose. Although injecting medication (18%) and higher out-of-pocket costs (17%) were deemed the most bothersome attributes, the majority (69%) noted their healthcare team understands how osteoporosis impacts their lives. In multivariable analyses, ease of preparation (OR = 2.62; 95% CI, 1.01-6.81; = 0.048) and fracture history (OR = 1.72; 95% CI, 1.03-2.86; = 0.037) were significantly associated with overall satisfaction. Ease of preparation was a predictor of higher satisfaction with treatment convenience (coefficient = 13.60; 95% CI, 8.08-19.12; = 0.00). Remembering to take the medication was a significant predictor of self-reported adherence (OR = 16.66; 95% CI, 3.30-84.24; = 0.001). In conclusion, the majority of patients were satisfied with ABL and found it convenient/easy to prepare and store. High self-reported adherence may be associated with positive patient experience including ease of use and adequate support from healthcare providers. © 2020 The Authors. published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.
尽管有多种骨质疏松症治疗方法可供选择，但依从性仍然不尽人意。一个促成因素可能是患者的治疗体验。这项在美国开展的多中心、回顾性病历审查与患者问卷调查相结合的研究纳入了骨折高危的绝经后女性，是第一项描述阿巴洛肽（ABL）注射剂真实世界患者体验的研究。美国8个地理位置分散的二级医疗机构参与了研究（n = 193）。平均年龄±标准差为67.4±8.62岁。大多数患者（86%）对ABL治疗方案满意，尤其是对制剂的简易性（82%）、储存的简易性（87%）和储存便利性（89%）满意，83%的患者认为这一特性很重要。大多数患者报告对ABL治疗方案完全满意，因为该方案使他们能够进行日常活动（85%）且方便融入日常日程安排（84%）。所有患者均报告按医嘱在下腹部注射ABL，83%的患者报告依从性为中等或较高。患者对针头尺寸满意（76%完全满意），93%的患者报告从未故意漏服一剂。尽管注射药物（18%）和较高的自付费用（17%）被认为是最麻烦的特性，但大多数（69%）患者指出其医疗团队了解骨质疏松症对他们生活的影响。在多变量分析中，制剂的简易性（OR = 2.62；95%CI，1.01 - 6.81；P = 0.048）和骨折病史（OR = 1.72；95%CI，1.03 - 2.86；P = 0.037）与总体满意度显著相关。制剂的简易性是对治疗便利性更高满意度的一个预测因素（系数 = 13.60；95%CI，8.08 - 19.12；P = 0.00）。记得服药是自我报告依从性的一个显著预测因素（OR = 16.66；95%CI，3.30 - 84.24；P = 0.001）。总之，大多数患者对ABL满意，且发现其制备和储存方便/简易。自我报告的高依从性可能与积极的患者体验相关，包括使用方便以及医疗服务提供者的充分支持。© 2020作者。由Wiley Periodicals LLC代表美国骨与矿物质研究学会出版。
