Yan Yinkun, Li Shengxu, Liu Yang, Bazzano Lydia, He Jiang, Mi Jie, Chen Wei
Department of Non-communicable Disease Management Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China.
Department of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans LA USA.
Pediatr Investig. 2021 Mar 22;5(1):21-27. doi: 10.1002/ped4.12248. eCollection 2021 Mar.
The impact of long-term burden of excessive body weight, beginning in childhood, on inflammatory status in adulthood has been poorly described.
To characterize the longitudinal body mass index (BMI) trajectory from childhood and examine its relationship with inflammatory status in adulthood.
We included 1285 adults who had 4-15 repeat measurements of BMI from childhood to adulthood. The area under the curve (AUC) of growth curves was calculated to characterize long-term burden (total AUC) and trends (incremental AUC) of BMI.
After adjusting for covariates, higher values of BMI in terms of childhood and adulthood, as well as total and incremental AUC, were strongly associated with elevated levels of adult C-reactive protein (CRP) in the four race-sex groups. There were significant differences in linear and nonlinear curve parameters between the normal and high CRP groups for all race-sex groups ( < 0.01). Compared with participants who had consistently low BMI in both childhood and adulthood, participants with high BMI in adulthood had higher CRP levels ( < 0.001), irrespective of their childhood BMI status; participants with high BMI in childhood but low BMI in adulthood had similar adult CRP levels.
The impact of excessive body weight on inflammation is cumulative and exacerbated over time. The influence of childhood overweight/obesity on inflammatory status in adulthood can be alleviated by reducing adiposity in adulthood.
从儿童期开始的长期超重负担对成年期炎症状态的影响鲜有描述。
描述从儿童期开始的纵向体重指数（BMI）轨迹，并研究其与成年期炎症状态的关系。
我们纳入了1285名成年人，他们从儿童期到成年期有4 - 15次重复的BMI测量值。计算生长曲线的曲线下面积（AUC）以表征BMI的长期负担（总AUC）和趋势（增量AUC）。
在调整协变量后，在四个种族 - 性别组中，儿童期和成年期的BMI较高值以及总AUC和增量AUC与成年期C反应蛋白（CRP）水平升高密切相关。所有种族 - 性别组的正常CRP组和高CRP组之间的线性和非线性曲线参数存在显著差异（<0.01）。与儿童期和成年期BMI一直较低的参与者相比，成年期BMI高的参与者CRP水平更高（<0.001），无论其儿童期BMI状况如何；儿童期BMI高但成年期BMI低的参与者成年期CRP水平相似。
超重对炎症的影响是累积性的，且会随着时间加剧。儿童期超重/肥胖对成年期炎症状态的影响可通过成年期减轻肥胖来缓解。
