Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China.
Arch Virol. 2021 Jul;166(7):1811-1817. doi: 10.1007/s00705-021-05008-y. Epub 2021 Mar 28.
Coronaviruses are a large family of important pathogens that cause human and animal diseases. At the end of 2019, a pneumonia epidemic caused by a novel coronavirus brought attention to coronaviruses. Exploring the interaction between the virus and its receptor will be helpful in developing preventive vaccines and therapeutic drugs. The coronavirus spike protein (S) plays an important role in both binding to receptors on host cells and fusion of the viral membrane with the host cell membrane. This review introduces the structure and function of the S protein and its receptor, focusing on the binding mode and binding region of both.
冠状病毒是一类重要病原体的大家族，能够引起人类和动物疾病。在 2019 年末，一种新型冠状病毒引起的肺炎疫情引起了人们对冠状病毒的关注。探索病毒与其受体之间的相互作用有助于开发预防性疫苗和治疗性药物。冠状病毒刺突蛋白（S）在病毒与宿主细胞受体结合以及病毒膜与宿主细胞膜融合过程中都发挥着重要作用。本综述介绍了 S 蛋白及其受体的结构和功能，重点介绍了两者的结合模式和结合区域。
