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[一名既往确诊的2型糖尿病患者出现伴有极度高血糖和高血糖诱导低钠血症的高渗高血糖状态(HHS)]

[Hyperosmolar Hyperglycemic State (HHS) with extreme hyperglycemia and hyperglycemia-induced hyponatremia in a patient with previously known diabetes mellitus type 2].

作者信息

Nilsson Konrad, Werner Jacob

机构信息

doktorand, ST-läkare, VO internmedicin, Visby lasarett; institutionen för medicinska vetenskaper, Uppsala universitet.

överläkare, VO internmedicin, Visby lasarett.

出版信息

Lakartidningen. 2021 Mar 26;118:20167.

Abstract

This case report covers a patient presenting unconscious to the emergency department with a serum glucose level of 125.6 mmol/L and an associated hyperglycemia-induced hyponatremia with a sodium level of 101 mmol/L. The glucose level is, to our knowledge, one of the most extreme values described in medical literature. Glucose and sodium levels were normalized following treatment with intravenous fluids, mainly Ringer's lactate solution and insulin infusion with an initial rate of 0,5 IU/kg/h. The patient needed ten days of hospital care, including five days at the intensive care unit. Shortly after discharge the patient had a complete recovery. However, the extreme values led to difficulties regarding correction rates, choice of treatment and monitoring, which is further discussed in the article.

摘要

本病例报告涵盖一名急诊时昏迷的患者,其血清葡萄糖水平为125.6 mmol/L,并伴有高血糖诱导的低钠血症,钠水平为101 mmol/L。据我们所知,该葡萄糖水平是医学文献中描述的最极端值之一。经静脉补液治疗后,葡萄糖和钠水平恢复正常,主要使用乳酸林格氏液和初始速率为0.5 IU/kg/h的胰岛素输注。患者需要住院治疗十天,其中包括在重症监护病房治疗五天。出院后不久,患者完全康复。然而,这些极端值在纠正率、治疗选择和监测方面带来了困难,本文将对此进行进一步讨论。

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