Gabrieli J D, Cohen N J, Corkin S
Department of Brain and Cognitive Sciences, MIT, Cambridge 02139.
Brain Cogn. 1988 Apr;7(2):157-77. doi: 10.1016/0278-2626(88)90027-9.
The integrity of several aspects of semantic memory (including knowledge of the meaning, lexical status, perception, and pronunciation of words and famous names) was examined in H.M., a patient with anterograde amnesia following bilateral medial temporal-lobe excision. Despite normal memory for such semantic knowledge acquired prior to the onset of his amnesia in 1953, H.M. showed a severe deficit in memory for semantic information encountered subsequently. In combination with the previously reported impairments in new learning shown by H.M., the deficits observed here point to an association between semantic and episodic memory, and do not lend support to a distinction between them. The acquisition of semantic and episodic information, therefore, appears to depend upon a common memory system that requires the intact functioning of medial temporal-lobe structures.
对H.M.进行了语义记忆几个方面完整性的检查（包括对单词和名人名字的意义、词汇地位、感知及发音的知识），H.M.是一名在双侧内侧颞叶切除后患有顺行性遗忘症的患者。尽管H.M.对1953年其失忆症发作前获得的此类语义知识有正常记忆，但他对随后遇到的语义信息的记忆存在严重缺陷。结合此前报道的H.M.在新学习方面的损伤，此处观察到的缺陷表明语义记忆和情景记忆之间存在关联，并不支持二者之间存在区别的观点。因此，语义信息和情景信息的获取似乎依赖于一个共同的记忆系统，该系统需要内侧颞叶结构的完整功能。
