Racle J P, Benkhadra A, Poy J Y, Gleizal B
Department of Anaesthesiology, General Hospital, Châlon sur Saône, France.
Br J Anaesth. 1988 Apr;60(5):508-14. doi: 10.1093/bja/60.5.508.
The effects of age were investigated on characteristics of spinal analgesia with hyperbaric bupivacaine in 38 younger patients (less than 50 yr: group I), and 48 older patients (greater than 80 yr: group II). Four millilitre of 0.375% bupivacaine in 2.5% dextrose was injected via the L3-4 space in a lateral position, and the patients were immediately turned supine. In group II, the time to maximum spread was significantly shorter, and the sensory spinal blockade higher (one dermatome) than in group I. The mean sensory recovery of the two uppermost segments did not differ between the two groups. The mean duration of analgesia at the L2 level was increased by only 15 min in the older group. Complete motor blockade of the lower limbs developed most rapidly in group II, while duration of all degrees of motor blockade did not differ significantly with age. Because of great individual variation, the clinical significance of such differences is limited. In the older group, there was a greater decrease in systolic arterial pressure from resting values, despite rapid infusion of lactated Ringer's solution.
研究了年龄对38例年轻患者（年龄小于50岁：I组）和48例老年患者（年龄大于80岁：II组）腰麻布比卡因脊髓镇痛特征的影响。于侧卧位经L3-4间隙注入4毫升含2.5%葡萄糖的0.375%布比卡因，随后患者立即转为仰卧位。与I组相比，II组达到最大扩散时间显著缩短，感觉性脊髓阻滞更高（高一个皮节）。两组最上方两个节段的平均感觉恢复无差异。老年组L2水平的平均镇痛持续时间仅增加15分钟。II组下肢完全运动阻滞发展最快，而不同程度运动阻滞的持续时间与年龄无显著差异。由于个体差异较大，这些差异的临床意义有限。在老年组中，尽管快速输注乳酸林格液，但收缩压较静息值下降幅度更大。
