Racle J P, Benkhadra A, Poy J Y, Gantheret O, Poli L, Brousse M, Gleizal B
Ann Fr Anesth Reanim. 1986;5(5):490-6. doi: 10.1016/s0750-7658(86)80035-1.
In 60 elderly patients, spinal anaesthesia for orthopaedic hip surgery was induced randomly with 15 mg bupivacaine 0.375% without glucose (Group I), 2.5% glucose (Group II) or 7.5% glucose (Group III), in 4 ml. The injection was made in the lateral position, and the patients turned supine immediately after. The onset, extent and duration of sensory and motor blockade, the cardiovascular effects and the quality of anaesthesia were evaluated. The hyperbaric solutions produced a greater cephalad spread of analgesia (T8,9 and T9,8 respectively) than the glucose-free solution (T10,5). The mean duration of analgesia at the L2 level with the isobaric solution was significantly greater: 187 min versus 171 min and 150 min with the hyperbaric solutions. All the patients had complete motor blockade of the lower limb. The mean duration of the motor block was significantly shorter for the 2.5% and 7.5% glucose solutions (137 and 125 min respectively for Bromage's degree 3) versus 170 min for the glucose-free solution. Although the pre-anaesthetic arterial pressures in the three groups did not differ significantly, the systolic, mean and diastolic arterial pressures decreased only by about 20 to 25% in all groups. It was suggested to take into account the more rapid infusion of lactated Ringer's solution (20 ml X kg-1) in Group III. Anaesthesia was satisfactory in 95% of patients in Group I and Group II, and 90% in Group III. Glucose-free bupivacaine produced a long-lasting blockade suitable for hip surgery of long duration.
在60例老年患者中,将15毫克0.375%不含葡萄糖的布比卡因(I组)、2.5%葡萄糖的布比卡因(II组)或7.5%葡萄糖的布比卡因(III组),以4毫升的量随机用于骨科髋关节手术的脊髓麻醉诱导。注射在侧卧位进行,注射后患者立即转为仰卧位。评估感觉和运动阻滞的起效、范围和持续时间、心血管效应以及麻醉质量。与不含葡萄糖的溶液(T10,5)相比,高比重溶液产生的镇痛头向扩散更大(分别为T8,9和T9,8)。等比重溶液在L2水平的平均镇痛持续时间显著更长:187分钟,而高比重溶液分别为171分钟和150分钟。所有患者下肢均有完全运动阻滞。2.5%和7.5%葡萄糖溶液的运动阻滞平均持续时间显著较短(布罗玛分级3级分别为137分钟和125分钟),而不含葡萄糖的溶液为170分钟。尽管三组麻醉前动脉压无显著差异,但所有组的收缩压、平均动脉压和舒张压仅下降约20%至25%。建议考虑III组中乳酸林格氏液输注更快(20毫升×千克-1)的情况。I组和II组95%的患者麻醉效果满意,III组为90%。不含葡萄糖的布比卡因产生了适合长时间髋关节手术的持久阻滞。